CD4+ and CD8+ T cell activation are associated with HIV DNA in resting CD4+ T cells.
PLoS One
; 9(10): e110731, 2014.
Article
en En
| MEDLINE
| ID: mdl-25340755
ABSTRACT
The association between the host immune environment and the size of the HIV reservoir during effective antiretroviral therapy is not clear. Progress has also been limited by the lack of a well-accepted assay for quantifying HIV during therapy. We examined the association between multiple measurements of HIV and T cell activation (as defined by markers including CD38, HLA-DR, CCR5 and PD-1) in 30 antiretroviral-treated HIV-infected adults. We found a consistent association between the frequency of CD4+ and CD8+ T cells expressing HLA-DR and the frequency of resting CD4+ T cells containing HIV DNA. This study highlights the need to further examine this relationship and to better characterize the biology of markers commonly used in HIV studies. These results may also have implications for reactivation strategies.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
ADN Viral
/
Activación de Linfocitos
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Linfocitos T CD4-Positivos
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Infecciones por VIH
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Linfocitos T CD8-positivos
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
PLoS One
Asunto de la revista:
CIENCIA
/
MEDICINA
Año:
2014
Tipo del documento:
Article