An overview of pre-ribosomal RNA processing in eukaryotes.
Wiley Interdiscip Rev RNA
; 6(2): 225-42, 2015.
Article
en En
| MEDLINE
| ID: mdl-25346433
ABSTRACT
Ribosomal RNAs are the most abundant and universal noncoding RNAs in living organisms. In eukaryotes, three of the four ribosomal RNAs forming the 40S and 60S subunits are borne by a long polycistronic pre-ribosomal RNA. A complex sequence of processing steps is required to gradually release the mature RNAs from this precursor, concomitant with the assembly of the 79 ribosomal proteins. A large set of trans-acting factors chaperone this process, including small nucleolar ribonucleoparticles. While yeast has been the gold standard for studying the molecular basis of this process, recent technical advances have allowed to further define the mechanisms of ribosome biogenesis in animals and plants. This renewed interest for a long-lasting question has been fueled by the association of several genetic diseases with mutations in genes encoding both ribosomal proteins and ribosome biogenesis factors, and by the perspective of new anticancer treatments targeting the mechanisms of ribosome synthesis. A consensus scheme of pre-ribosomal RNA maturation is emerging from studies in various kinds of eukaryotic organisms. However, major differences between mammalian and yeast pre-ribosomal RNA processing have recently come to light.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Precursores del ARN
/
Procesamiento Postranscripcional del ARN
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Wiley Interdiscip Rev RNA
Año:
2015
Tipo del documento:
Article