Variación Genética; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/metabolismo; Receptores del Ligando Inductor de Apoptosis Relacionado con TNF/metabolismo; Ligando Inductor de Apoptosis Relacionado con TNF/genética; Animales; Apoptosis/efectos de los fármacos; Apoptosis/genética; Línea Celular Tumoral; Modelos Animales de Enfermedad; Femenino; Expresión Génica; Humanos; Ratones; Mutación; Neoplasias Pancreáticas/patología; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Proteínas Recombinantes/farmacología; Ligando Inductor de Apoptosis Relacionado con TNF/administración & dosificación; Ligando Inductor de Apoptosis Relacionado con TNF/metabolismo; Ligando Inductor de Apoptosis Relacionado con TNF/farmacología; Transfección; Carga Tumoral/efectos de los fármacos; Ensayos Antitumor por Modelo de Xenoinjerto

AML, Acute myeloid leukemia; ANOVA, Analysis of variance between groups; Apoptosis; BSA, Bovine Serum Albumin; Bcl-xL, B-cell lymphoma-extra large; CMV, Cytomegalie virus; CuZnSOD, Copper-Zinc Superoxide Dismutase; DMEM, Dulbecco's modified Eagle's medium; DNA, Deoxyribonucleic acid; DR4 specific TRAIL variant; EGFP, Enhanced green fluorescent protein; ELISA, Enzyme-linked immunosorbent assay; FACS, Fluorescence-activated cell sorting; FADD, Fas-associated protein with death domain; FBS, Fetal bovine serum; FIB, Fibrillin; FLIP, FLICE-like inhibitory protein; Furin CS, Furin cleavage site; IFN-g, Interferon-gamma; ILZ, Isoleucine zipper; MSC, Mesenchymal stem cell; NF-κB, Nuclear factor kappa-light-chain-enhancer of activated B cells; OPG, Osteoprogerin; PBS, Phosphate buffered saline; PCR, Polymerase chain reaction; RANKL, Receptor activator of nuclear factor kappa-B ligand; RNAi, RNA interference; RPMI 1640 medium, Roswell Park Memorial Institute 1640 medium; SDS, Sodium dodecyl sulphate; SDS-PAGE, SDS-Polyacrylamide gel electrophoresis; SEM, Standard error of the mean; TNF, Tumor necrosis factor; TRAIL; TRAIL receptor; TRAIL, TNF-related apoptosis-inducing ligand; TRAIL-R1/DR4, TRAIL-receptor 1/Death ­ receptor 4; TRAIL-R2/DR5, TRAIL-receptor 2/ Death ­ receptor 5; TRAIL-R3/DcR1, TRAIL-receptor 3/Decoy-receptor 1; TRAIL-R4/DcR2, TRAIL-receptor 4/Decoy-receptor 2; XIAP; XIAP, X-linked Inhibitor of apoptosis protein; pancreatic cancer; rTRAIL, recombinant TNF-related apoptosis-inducing ligand; sTRAIL, soluble TNF-related apoptosis-inducing ligand; sh-sequence, short-hairpin sequence