Morbidly "Healthy" Obese Are Not Metabolically Healthy but Less Metabolically Imbalanced Than Those with Type 2 Diabetes or Dyslipidemia.
Obes Surg
; 25(8): 1380-91, 2015 Aug.
Article
en En
| MEDLINE
| ID: mdl-25515498
ABSTRACT
BACKGROUND:
We have investigated the differences between metabolically "healthy" morbidly obese patients and those with comorbidities. MATERIALS ANDMETHODS:
Thirty-two morbidly obese patients were divided by the absence ("healthy" DM-DL-) or presence of comorbidities (dyslipidemic DM-DL+, or dyslipidemic and with type 2 diabetes DM+DL+). We have studied various plasma parameters and gene expression adipose tissue, before and after gastric bypass.RESULTS:
The group DM+DL+ tends to have lower values than the other two groups for anthropometric parameters. Regarding the satiety parameters, only leptin (p = 0.0024) showed a significant increase with comorbidities. Lipid parameters showed significant differences among groups, except for phospholipids and NEFA. For insulin resistance parameters, only glucose (p < 0.0001) was higher in DM+DL+ patients, but not insulin or homeostasis model assessment of insulin resistance (HOMA-IR). The gene expression of adiponectin, insulin receptor (INSR) and glucose receptor-4 (GLUT4), in the subcutaneous fat, decreased in all groups vs. a non-obese control. Interleukin-6 (IL6) and the inhibitor of plasminogen activator type 1 (PAI-1) genes decreased only in DM-DL+ and DM+DL+, but not in "healthy" patients. Leptin increased in all groups vs. the non-obese control. The visceral fat from DM+DL+ patients showed a sharp decrease in adiponectin, GLUT4, IL6 and PAI-1. All parameters mentioned above improved very significantly by surgery, independent of the occurrence of comorbidities.CONCLUSIONS:
The morbidly obese "healthy" individual is not really metabolically healthy, but morbidly obese individuals with diabetes and dyslipidemia are more metabolically imbalanced.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Obesidad Mórbida
/
Diabetes Mellitus Tipo 2
/
Dislipidemias
/
Obesidad Metabólica Benigna
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Obes Surg
Asunto de la revista:
METABOLISMO
Año:
2015
Tipo del documento:
Article