Pharmacokinetics of intravenous ketorolac in cats undergoing gonadectomy.
N Z Vet J
; 63(3): 162-6, 2015 May.
Article
en En
| MEDLINE
| ID: mdl-25523103
ABSTRACT
AIM:
To determine the pharmacokinetics of ketorolac tromethamine (0.5â mg/kg) when administered I/V to cats undergoing gonadectomy.METHODS:
Ketorolac was administered to nine female and three male shorthair domestic cats as an I/V bolus of 0.5â mg/kg after intubation, and 20 minutes prior to ovariectomy or orchiectomy. Intra-operative cardiorespiratory variables were monitored and blood samples were collected over 24 hours. Concentrations of ketorolac in serum were determined by high-performance liquid chromatography to establish pharmacokinetic parameters.RESULTS:
During surgery, mean end tidal isoflurane concentration was 1.63 (SD 0.24)% and normocapnia and spontaneous ventilation were maintained in all animals. The kinetics of ketorolac was described by a two-compartment model. The distribution and elimination half-lives were 0.09 (SD 0.06) and 4.14 (SD 1.18) hours, respectively. The body clearance was 56.8 (SD 33.1) mL/h/kg. The volume of distribution at steady-state and the mean residence time were 323.9 (SD 115.7) mL/kg and 6.47 (SD 2.86) hours, respectively. CONCLUSION AND CLINICAL RELEVANCE On the basis of the results, concentrations of ketorolac in serum in cats were above the human effective concentrations for 5-6 hours postoperatively. However, other studies including a control group are advocated to further investigate the ketorolac kinetics and the analgesic efficacy in this species.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Orquiectomía
/
Ovariectomía
/
Gatos
/
Ketorolaco
/
Histerectomía
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
N Z Vet J
Año:
2015
Tipo del documento:
Article