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Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.
Guillemyn, Karel; Kleczkowska, Patrycia; Lesniak, Anna; Dyniewicz, Jolanta; Van der Poorten, Olivier; Van den Eynde, Isabelle; Keresztes, Attila; Varga, Eva; Lai, Josephine; Porreca, Frank; Chung, Nga N; Lemieux, Carole; Mika, Joanna; Rojewska, Ewelina; Makuch, Wioletta; Van Duppen, Joost; Przewlocka, Barbara; Vanden Broeck, Jozef; Lipkowski, Andrzej W; Schiller, Peter W; Tourwé, Dirk; Ballet, Steven.
Afiliación
  • Guillemyn K; Laboratory of Organic Chemistry, Departments of Chemistry and Bio-engineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. Electronic address: kguillem@vub.ac.be.
  • Kleczkowska P; Neuropeptide Laboratory, Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Street, PL 02-106, Warsaw, Poland; Department of Pharmacodynamics, Centre for Preclinical Research and Technology (CePT), Medical University of Warsaw, Warsaw, Poland. Electronic address: hazufiel@wp.pl.
  • Lesniak A; Neuropeptide Laboratory, Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Street, PL 02-106, Warsaw, Poland. Electronic address: alesniak@imdik.pan.pl.
  • Dyniewicz J; Neuropeptide Laboratory, Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Street, PL 02-106, Warsaw, Poland. Electronic address: jolantadyniewicz@gmail.com.
  • Van der Poorten O; Laboratory of Organic Chemistry, Departments of Chemistry and Bio-engineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. Electronic address: Olivier.Van.Der.Poorten@vub.ac.be.
  • Van den Eynde I; Laboratory of Organic Chemistry, Departments of Chemistry and Bio-engineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. Electronic address: vandeneynde.isabelle@gmail.com.
  • Keresztes A; Department of Pharmacology, University of Arizona, 1501 N. Campbell Ave, Tucson AZ, 85724-5050, USA. Electronic address: keratti@freemail.hu.
  • Varga E; Department of Pharmacology, University of Arizona, 1501 N. Campbell Ave, Tucson AZ, 85724-5050, USA. Electronic address: evarga@email.arizona.edu.
  • Lai J; Department of Pharmacology, University of Arizona, 1501 N. Campbell Ave, Tucson AZ, 85724-5050, USA. Electronic address: lai@email.arizona.edu.
  • Porreca F; Department of Pharmacology, University of Arizona, 1501 N. Campbell Ave, Tucson AZ, 85724-5050, USA. Electronic address: frankp@email.arizona.edu.
  • Chung NN; Department of Chemical Biology and Peptide Research, Clinical Research Institute, 110 Avenue Des Pins Ouest, Montreal, QC, H2W1R7, Canada. Electronic address: NgocNga.chung@ircm.qc.ca.
  • Lemieux C; Department of Chemical Biology and Peptide Research, Clinical Research Institute, 110 Avenue Des Pins Ouest, Montreal, QC, H2W1R7, Canada. Electronic address: carole-lemieux@hotmail.com.
  • Mika J; Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343, Kraków, Poland. Electronic address: joamika@if-pan.krakow.pl.
  • Rojewska E; Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343, Kraków, Poland. Electronic address: rojewska@if-pan.krakow.pl.
  • Makuch W; Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343, Kraków, Poland. Electronic address: makuch@if-pan.krakow.pl.
  • Van Duppen J; Animal Physiology and Neurobiology Department, University of Leuven (KU Leuven), Naamsestraat 59, 3000 Leuven, Belgium. Electronic address: Joost.VanDuppen@bio.kuleuven.be.
  • Przewlocka B; Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343, Kraków, Poland. Electronic address: barbara.przewlocka@gmail.com.
  • Vanden Broeck J; Animal Physiology and Neurobiology Department, University of Leuven (KU Leuven), Naamsestraat 59, 3000 Leuven, Belgium. Electronic address: Jozef.VandenBroeck@bio.kuleuven.be.
  • Lipkowski AW; Neuropeptide Laboratory, Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego Street, PL 02-106, Warsaw, Poland. Electronic address: andrzej@lipkowski.org.
  • Schiller PW; Department of Chemical Biology and Peptide Research, Clinical Research Institute, 110 Avenue Des Pins Ouest, Montreal, QC, H2W1R7, Canada. Electronic address: Peter.Schiller@ircm.qc.ca.
  • Tourwé D; Laboratory of Organic Chemistry, Departments of Chemistry and Bio-engineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. Electronic address: datourwe@vub.ac.be.
  • Ballet S; Laboratory of Organic Chemistry, Departments of Chemistry and Bio-engineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. Electronic address: sballet@vub.ac.be.
Eur J Med Chem ; 92: 64-77, 2015 Mar 06.
Article en En | MEDLINE | ID: mdl-25544687
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Receptores Opioides / Peptidomiméticos / Antagonistas del Receptor de Neuroquinina-1 Idioma: En Revista: Eur J Med Chem Año: 2015 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Receptores Opioides / Peptidomiméticos / Antagonistas del Receptor de Neuroquinina-1 Idioma: En Revista: Eur J Med Chem Año: 2015 Tipo del documento: Article