Kidney transplant recipients carrying the CYP3A4*22 allelic variant have reduced tacrolimus clearance and often reach supratherapeutic tacrolimus concentrations.

Pallet, N; Jannot, A-S; El Bahri, M; Etienne, I; Buchler, M; de Ligny, B H; Choukroun, G; Colosio, C; Thierry, A; Vigneau, C; Moulin, B; Le Meur, Y; Heng, A-E; Subra, J-F; Legendre, C; Beaune, P; Alberti, C; Loriot, M A; Thervet, E

Pallet, N; Jannot, A-S; El Bahri, M; Etienne, I; Buchler, M; de Ligny, B H; Choukroun, G; Colosio, C; Thierry, A; Vigneau, C; Moulin, B; Le Meur, Y; Heng, A-E; Subra, J-F; Legendre, C; Beaune, P; Alberti, C; Loriot, M A; Thervet, E.

Afiliación

Pallet N; Clinical Chemistry, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Paris, France; Department of Nephrology, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Paris, France; Paris Descartes University, Paris, France; Sorbonne Paris Cité, INSERM UMRS, 1147, Paris, France.

Am J Transplant ; 15(3): 800-5, 2015 Mar.

Article en En | MEDLINE | ID: mdl-25588704

Asunto(s)

Alelos; Citocromo P-450 CYP3A/genética; Inmunosupresores/farmacocinética; Trasplante de Riñón; Tacrolimus/farmacocinética; Adulto; Femenino; Humanos; Masculino; Persona de Mediana Edad

Palabras clave

Clinical research; immune modulation; immunosuppressant, calcineurin inhibitor: tacrolimus, pharmacokinetics; nephrology, immunosuppression; pharmacodynamics, genetics; pharmacology, kidney transplantation; practice

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Trasplante de Riñón / Tacrolimus / Alelos / Citocromo P-450 CYP3A / Inmunosupresores Tipo de estudio: Clinical_trials Idioma: En Revista: Am J Transplant Asunto de la revista: TRANSPLANTE Año: 2015 Tipo del documento: Article

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