Multifunctional drug nanocarriers formed by cRGD-conjugated ßCD-PAMAM-PEG for targeted cancer therapy.
Colloids Surf B Biointerfaces
; 126: 590-597, 2015 Feb 01.
Article
en En
| MEDLINE
| ID: mdl-25591850
ABSTRACT
Polyamidoamine (PAMAM) dendrimer was conjugated with both carboxymethyl-ß-cyclodextrin (ßCD) and poly(ethylene glycol) (PEG). Cyclic RGD peptide, used as a tumor targeting ligand, was then selectively conjugated onto the distal ends of the PEG arms. The resulting ßCD-PAMAM-PEG-cRGD polymer was able to form stable and uniform nanoparticles (NPs) in aqueous solution. Doxorubicin (Dox), a model hydrophobic anticancer drug, was effectively encapsulated in the NPs via an inclusion complex formed between the drug and ßCD. The Dox loading level was 16.8 wt%. The cellular uptake of cRGD-conjugated Dox-loaded NPs in the U87MG cell line was much higher than that of non-targeted NPs. Furthermore, the anti-proliferative effect of the cRGD-conjugated NPs was superior to that of free drug and non-targeted NPs. These results suggest that NPs formed by ßCD-PAMAM-PEG-cRGD with a high drug payload may significantly improve the anticancer efficacy by tumor-targeted delivery and enhanced cellular uptake.
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1
Base de datos:
MEDLINE
Asunto principal:
Péptidos Cíclicos
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Poliaminas
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Polietilenglicoles
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Portadores de Fármacos
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Nanoestructuras
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Antineoplásicos
Idioma:
En
Revista:
Colloids Surf B Biointerfaces
Asunto de la revista:
QUIMICA
Año:
2015
Tipo del documento:
Article