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Low Dopamine D2/D3 Receptor Availability is Associated with Steep Discounting of Delayed Rewards in Methamphetamine Dependence.
Ballard, Michael E; Mandelkern, Mark A; Monterosso, John R; Hsu, Eustace; Robertson, Chelsea L; Ishibashi, Kenji; Dean, Andy C; London, Edythe D.
Afiliación
  • Ballard ME; Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles (Drs Ballard, Ishibashi, Dean, and London); Department of Molecular and Medical Pharmacology, University of California Los Angeles (Robertson and Dr London); Brain Research Institute, University of California L
  • Mandelkern MA; Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles (Drs Ballard, Ishibashi, Dean, and London); Department of Molecular and Medical Pharmacology, University of California Los Angeles (Robertson and Dr London); Brain Research Institute, University of California L
  • Monterosso JR; Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles (Drs Ballard, Ishibashi, Dean, and London); Department of Molecular and Medical Pharmacology, University of California Los Angeles (Robertson and Dr London); Brain Research Institute, University of California L
  • Hsu E; Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles (Drs Ballard, Ishibashi, Dean, and London); Department of Molecular and Medical Pharmacology, University of California Los Angeles (Robertson and Dr London); Brain Research Institute, University of California L
  • Robertson CL; Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles (Drs Ballard, Ishibashi, Dean, and London); Department of Molecular and Medical Pharmacology, University of California Los Angeles (Robertson and Dr London); Brain Research Institute, University of California L
  • Ishibashi K; Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles (Drs Ballard, Ishibashi, Dean, and London); Department of Molecular and Medical Pharmacology, University of California Los Angeles (Robertson and Dr London); Brain Research Institute, University of California L
  • Dean AC; Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles (Drs Ballard, Ishibashi, Dean, and London); Department of Molecular and Medical Pharmacology, University of California Los Angeles (Robertson and Dr London); Brain Research Institute, University of California L
  • London ED; Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles (Drs Ballard, Ishibashi, Dean, and London); Department of Molecular and Medical Pharmacology, University of California Los Angeles (Robertson and Dr London); Brain Research Institute, University of California L
Int J Neuropsychopharmacol ; 18(7): pyu119, 2015 Jan 20.
Article en En | MEDLINE | ID: mdl-25603861
ABSTRACT

BACKGROUND:

Individuals with substance use disorders typically exhibit a predilection toward instant gratification with apparent disregard for the future consequences of their actions. Indirect evidence suggests that low dopamine D2-type receptor availability in the striatum contributes to the propensity of these individuals to sacrifice long-term goals for short-term gain; however, this possibility has not been tested directly. We investigated whether striatal D2/D3 receptor availability is negatively correlated with the preference for smaller, more immediate rewards over larger, delayed alternatives among research participants who met DSM-IV criteria for methamphetamine (MA) dependence.

METHODS:

Fifty-four adults (n = 27 each MA-dependent, non-user controls) completed the Kirby Monetary Choice Questionnaire, and underwent positron emission tomography scanning with [(18)F]fallypride.

RESULTS:

MA users displayed steeper temporal discounting (p = 0.030) and lower striatal D2/D3 receptor availability (p < 0.0005) than controls. Discount rate was negatively correlated with striatal D2/D3 receptor availability, with the relationship reaching statistical significance in the combined sample (r = -0.291, p = 0.016) and among MA users alone (r = -0.342, p = 0.041), but not among controls alone (r = -0.179, p = 0.185); the slopes did not differ significantly between MA users and controls (p = 0.5).

CONCLUSIONS:

These results provide the first direct evidence of a link between deficient D2/D3 receptor availability and steep temporal discounting. This finding fits with reports that low striatal D2/D3 receptor availability is associated with a higher risk of relapse among stimulant users, and may help to explain why some individuals choose to continue using drugs despite knowledge of their eventual negative consequences. Future research directions and therapeutic implications are discussed.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Recompensa / Receptores de Dopamina D2 / Trastornos Relacionados con Anfetaminas / Cuerpo Estriado / Tomografía de Emisión de Positrones / Receptores de Dopamina D3 / Metanfetamina Tipo de estudio: Risk_factors_studies Idioma: En Revista: Int J Neuropsychopharmacol Asunto de la revista: NEUROLOGIA / PSICOFARMACOLOGIA Año: 2015 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Recompensa / Receptores de Dopamina D2 / Trastornos Relacionados con Anfetaminas / Cuerpo Estriado / Tomografía de Emisión de Positrones / Receptores de Dopamina D3 / Metanfetamina Tipo de estudio: Risk_factors_studies Idioma: En Revista: Int J Neuropsychopharmacol Asunto de la revista: NEUROLOGIA / PSICOFARMACOLOGIA Año: 2015 Tipo del documento: Article