Iodine(III)-mediated oxidative cross-coupling of enamines and propargylamines under metal-free conditions: an alternative way to prepare highly substituted 3-pyrrolines.

ABSTRACT

A PhIO/Bu4NI-mediated oxidative cross-coupling reaction between enamines and propargylamines under metal-free conditions has been developed. Bu4NI works as an activator of PhIO. The resulting coupling products are ready to undergo copper(II)-mediated electrophilic cyclization to form highly substituted 3-pyrrolines.