Role of ß-isomerized C-terminal telopeptides (ß-CTx) and total procollagen type 1 amino-terminal propeptide (tP1NP) as osteosarcoma biomarkers.
Int J Clin Exp Med
; 8(1): 890-6, 2015.
Article
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| MEDLINE
| ID: mdl-25785071
ABSTRACT
INTRODUCTION:
Few serum markers are valid and useful for the diagnosis or therapeutic effect monitoring of osteosarcoma. This study aimed to investigate the role of ß-isomerized C-terminal telopeptides (ß-CTx) and total procollagen type 1 amino-terminal propeptide (tP1NP) as serological biomarkers for osteosarcoma patients. MATERIALS ANDMETHODS:
A total of 48 patients with osteosarcoma and 55 healthy volunteers were investigated. Serum ß-CTx and tP1NP levels were measured by electrochemiluminescence immunoassay. Data were analyzed by t test with Walth's correction and receiver operating characteristic (ROC) curve analysis.RESULTS:
The baseline levels of ß-CTx and tP1NP were found to be significantly higher in patients with osteosarcoma than the healthy volunteers. The mean areas under the ROC curves were 0.919 (range, 0.864-0.973) for ß-CTx and 0.866 (range, 0.792-0.939) for tP1NP. The levels of ß-CTx and tP1NP were lower in patients with stable disease after operation than those before operation.CONCLUSION:
These findings support our hypothesis that ß-CTx and tP1NP are promising serum biomarkers for diagnosing or monitoring osteosarcoma.
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Base de datos:
MEDLINE
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Int J Clin Exp Med
Año:
2015
Tipo del documento:
Article