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A rare case of cerebellar agenesis: a probabilistic Constrained Spherical Deconvolution tractographic study.
Mormina, Enricomaria; Briguglio, Marilena; Morabito, Rosa; Arrigo, Alessandro; Marino, Silvia; Di Rosa, Gabriella; Micalizzi, Alessia; Valente, Enza Maria; Salpietro, Vincenzo; Vinci, Sergio Lucio; Longo, Marcello; Granata, Francesca.
Afiliación
  • Mormina E; Neuroradiology Unit - Department of Biomedical Sciences and Morpho-Functional Imaging, University of Messina, via Consolare Valeria, 1 A.O.U. Policlinico "G. Martino", 98125, Messina, Italy.
  • Briguglio M; Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences, University of Messina, Messina, Italy.
  • Morabito R; Neuroradiology Unit - Department of Biomedical Sciences and Morpho-Functional Imaging, University of Messina, via Consolare Valeria, 1 A.O.U. Policlinico "G. Martino", 98125, Messina, Italy.
  • Arrigo A; Neuroradiology Unit - Department of Biomedical Sciences and Morpho-Functional Imaging, University of Messina, via Consolare Valeria, 1 A.O.U. Policlinico "G. Martino", 98125, Messina, Italy. alessandro.arrigo@hotmail.com.
  • Marino S; IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy.
  • Di Rosa G; Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences, University of Messina, Messina, Italy.
  • Micalizzi A; IRCCS Casa Sollievo della Sofferenza, CSS-Mendel Laboratory, San Giovanni Rotondo, Italy.
  • Valente EM; Department of Biological and Environmental Science, University of Messina, Messina, Italy.
  • Salpietro V; IRCCS Casa Sollievo della Sofferenza, CSS-Mendel Laboratory, San Giovanni Rotondo, Italy.
  • Vinci SL; Section of Neurosciences, Department of Medicine and Surgery, University of Salerno, Salerno, Italy.
  • Longo M; Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences, University of Messina, Messina, Italy.
  • Granata F; Neuroradiology Unit - Department of Biomedical Sciences and Morpho-Functional Imaging, University of Messina, via Consolare Valeria, 1 A.O.U. Policlinico "G. Martino", 98125, Messina, Italy.
Brain Imaging Behav ; 10(1): 158-67, 2016 Mar.
Article en En | MEDLINE | ID: mdl-25832852
Aim of this study is to show the potential of probabilistic tractographic techniques, based on the Constrained Spherical Deconvolution (CSD) algorithms, in recognizing white matter fiber bundle anomalies in patients with complex cerebral malformations, such as cerebellar agenesis. The morphological and tractographic study of a 17-year-old male patient affected by cerebellar agenesis was performed by using a 3Tesla MRI scanner. Genetic and neuropsychological tests were carried out. An MRI morphological study showed the absence of both cerebellar hemispheres and the flattening of the anterior side of the pons. Moreover, it showed a severe vermian hypoplasia with a minimal vermian residual. The study recognized two thin cerebellar remnants, medially in contact with the small vermian residual, at the pontine level. The third ventricle, morphologically normal, communicated with a permagna cerebello-medullary cistern. Probabilistic CSD tractography identified some abnormal and aberrant infratentorial tracts, symmetrical on both sides. In particular, the transverse pontine fibers were absent and the following tracts with aberrant trajectories have been identified: "cerebello-thalamic" tracts; "fronto-cerebellar" tracts; and ipsilateral and contralateral "spino-cerebellar" tracts. Abnormal tracts connecting the two thin cerebellar remnants have also been detected. There were no visible alterations in the main supratentorial tracts in either side. Neuropsychiatric evaluation showed moderate cognitive-motor impairment with discrete adaptive compensation. Probabilistic CSD tractography is a promising technique that overcome reconstruction biases of other diffusion tensor-based approaches and allowed us to recognize, in a patient with cerebellar agenesis, abnormal tracts and aberrant trajectories of normally existing tracts.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Algoritmos / Procesamiento de Imagen Asistido por Computador / Cerebelo / Imagen de Difusión por Resonancia Magnética Tipo de estudio: Prognostic_studies Idioma: En Revista: Brain Imaging Behav Asunto de la revista: CEREBRO / CIENCIAS DO COMPORTAMENTO / DIAGNOSTICO POR IMAGEM Año: 2016 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Algoritmos / Procesamiento de Imagen Asistido por Computador / Cerebelo / Imagen de Difusión por Resonancia Magnética Tipo de estudio: Prognostic_studies Idioma: En Revista: Brain Imaging Behav Asunto de la revista: CEREBRO / CIENCIAS DO COMPORTAMENTO / DIAGNOSTICO POR IMAGEM Año: 2016 Tipo del documento: Article