Single-dose attenuated Vesiculovax vaccines protect primates against Ebola Makona virus.
Nature
; 520(7549): 688-691, 2015 Apr 30.
Article
en En
| MEDLINE
| ID: mdl-25853476
ABSTRACT
The family Filoviridae contains three genera, Ebolavirus (EBOV), Marburg virus, and Cuevavirus. Some members of the EBOV genus, including Zaire ebolavirus (ZEBOV), can cause lethal haemorrhagic fever in humans. During 2014 an unprecedented ZEBOV outbreak occurred in West Africa and is still ongoing, resulting in over 10,000 deaths, and causing global concern of uncontrolled disease. To meet this challenge a rapid-acting vaccine is needed. Many vaccine approaches have shown promise in being able to protect nonhuman primates against ZEBOV. In response to the current ZEBOV outbreak several of these vaccines have been fast tracked for human use. However, it is not known whether any of these vaccines can provide protection against the new outbreak Makona strain of ZEBOV. One of these approaches is a first-generation recombinant vesicular stomatitis virus (rVSV)-based vaccine expressing the ZEBOV glycoprotein (GP) (rVSV/ZEBOV). To address safety concerns associated with this vector, we developed two candidate, further-attenuated rVSV/ZEBOV vaccines. Both attenuated vaccines produced an approximately tenfold lower vaccine-associated viraemia compared to the first-generation vaccine and both provided complete, single-dose protection of macaques from lethal challenge with the Makona outbreak strain of ZEBOV.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Vacunas Atenuadas
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Vesiculovirus
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Fiebre Hemorrágica Ebola
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Vacunas contra el Virus del Ébola
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Ebolavirus
País/Región como asunto:
Africa
Idioma:
En
Revista:
Nature
Año:
2015
Tipo del documento:
Article