Structural and functional characterization of tumor suppressors TIG3 and H-REV107.
FEBS Lett
; 589(11): 1179-86, 2015 May 08.
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| ID: mdl-25871522
ABSTRACT
H-REV107-like family proteins TIG3 and H-REV107 are class II tumor suppressors. Here we report that the C-terminal domains (CTDs) of TIG3 and H-REV107 can induce HeLa cell death independently. The N-terminal domain (NTD) of TIG3 enhances the cell death inducing ability of CTD, while NTD of H-REV107 plays an inhibitory role. The solution structure of TIG3 NTD is very similar to that of H-REV107 in overall fold. However, the CTD binding regions on NTD are different between TIG3 and H-REV107, which may explain their functional difference. As a result, the flexible main loop of H-REV107, but not that of TIG3, is critical for its NTD to modulate its CTD in inducing cell death.
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Base de datos:
MEDLINE
Asunto principal:
Receptores de Ácido Retinoico
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Proteínas Supresoras de Tumor
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Fosfolipasas A2 Calcio-Independiente
Idioma:
En
Revista:
FEBS Lett
Año:
2015
Tipo del documento:
Article