Neuroprotective effect of resveratrol against glutamate-induced excitotoxicity.
Adv Clin Exp Med
; 24(1): 161-5, 2015.
Article
en En
| MEDLINE
| ID: mdl-25923101
ABSTRACT
As the major neurotransmitter in the mammalian central nervous system (CNS), excessive extracellular glutamate (Glu) can activate the Glu receptors and neuronal calcium (Ca2+) overload, then produce neurotoxicity, which is a common pathway for neuronal injury or death, and is associated with acute and chronic neurodegenerative diseases. Therefore, it has been a therapeutic strategy to investigate neuroprotective effects against Glu-induced neurotoxicity for treating both acute and chronic forms of neurodegeneration. Resveratrol (Res), as a naturally occurring polyphenol mainly found in grapes and red wine, has shown a neuroprotective effect in a variety of experimental models for neurodegenerative diseases in vitro and in vivo. This review will focus on the neuroprotective effect of Res against Glu-induced excitotoxicity in neurodegenerative diseases by blocking different Glu receptors and Ca2+ ion channels.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Estilbenos
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Fármacos Neuroprotectores
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Ácido Glutámico
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Antagonistas de Aminoácidos Excitadores
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Enfermedades Neurodegenerativas
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Neuronas
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Adv Clin Exp Med
Año:
2015
Tipo del documento:
Article