Antitumor activity of tatariside F isolated from roots of Fagopyrum tataricum (L.) Gaertn against H22 hepatocellular carcinoma via up-regulation of p53.

Peng, Wei; Hu, Changling; Shu, Zhiheng; Han, Ting; Qin, Luping; Zheng, Chengjian

Peng, Wei; Hu, Changling; Shu, Zhiheng; Han, Ting; Qin, Luping; Zheng, Chengjian.

Afiliación

Peng W; Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, P.R. China; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, P.R. China.
Hu C; Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, P.R. China; Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, P.R. China.
Shu Z; Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, P.R. China.
Han T; Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, P.R. China.
Qin L; Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, P.R. China. Electronic address: qinsmmu@126.com.
Zheng C; Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, P.R. China. Electronic address: zhengchengjian@smmu.edu.cn.

Phytomedicine ; 22(7-8): 730-6, 2015 Jul 15.

Article en En | MEDLINE | ID: mdl-26141759

Asunto(s)

Antineoplásicos Fitogénicos/farmacología; Carcinoma Hepatocelular/patología; Fagopyrum/química; Flavonoides/farmacología; Neoplasias Hepáticas/patología; Animales; Antineoplásicos Fitogénicos/aislamiento & purificación; Apoptosis/efectos de los fármacos; Línea Celular Tumoral/efectos de los fármacos; Flavonoides/aislamiento & purificación; Regulación Neoplásica de la Expresión Génica; Humanos; Hígado/efectos de los fármacos; Ratones; Ratones Endogámicos ICR; Estructura Molecular; Raíces de Plantas/química; Proteínas Proto-Oncogénicas c-bcl-2/metabolismo; Proteína p53 Supresora de Tumor/metabolismo; Ensayos Antitumor por Modelo de Xenoinjerto; Proteína X Asociada a bcl-2/metabolismo

Palabras clave

Apoptosis; Fagopyrum tataricum (L.) Gaertn; H22 cell line; Hepatocellular carcinoma; Tatariside F; p53

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Flavonoides / Carcinoma Hepatocelular / Fagopyrum / Neoplasias Hepáticas / Antineoplásicos Fitogénicos Idioma: En Revista: Phytomedicine Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2015 Tipo del documento: Article

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