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Towards host-directed therapies for tuberculosis.
Zumla, Alimuddin; Maeurer, Markus; Chakaya, Jeremiah; Hoelscher, Michael; Ntoumi, Francine; Rustomjee, Roxana; Vilaplana, Cristina; Yeboah-Manu, Dorothy; Rasolof, Voahangy; Munderi, Paula; Singh, Nalini; Aklillu, Eleni; Padayatchi, Nesri; Macete, Eusebio; Kapata, Nathan; Mulenga, Modest; Kibiki, Gibson; Mfinanga, Sayoki; Nyirenda, Thomas; Maboko, Leonard; Garcia-Basteiro, Alberto; Rakotosamimanana, Niaina; Bates, Matthew; Mwaba, Peter; Reither, Klaus; Gagneux, Sebastien; Edwards, Sarah; Mfinanga, Elirehema; Abdulla, Salim; Cardona, Pere-Joan; Russell, James B W; Gant, Vanya; Noursadeghi, Mahdad; Elkington, Paul; Bonnet, Maryline; Menendez, Clara; Dieye, Tandakha N; Diarra, Bassirou; Maiga, Almoustapha; Aseffa, Abraham; Parida, Shreemanta; Wejse, Christian; Petersen, Eskild; Kaleebu, Pontiano; Oliver, Matt; Craig, Gill; Corrah, Tumena; Tientcheu, Leopold; Antonio, Martin; Rao, Martin.
Afiliación
  • Zumla A; 1] Division of Infection and Immunity at the University College London (UCL), London, UK and National Institute of Health Research's Biomedical Research Centre UCL Hospitals National Health Service Foundation Trust, Royal Free Campus, 2nd Floor, Rowland Hill Street, London NW3 2PF, UK. [2] Departmen
  • Maeurer M; Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet and Center for Allogeneic Stem Cell Transplantation, Karolinska Hospital, Hälsovägen, SE-14186 Stockholm, Sweden.
  • Chakaya J; Kenya Medical Research Institute, Nairobi, Kenya.
  • Hoelscher M; Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich (LMU), and DZIF German Centre for Infection Research, Munich, Germany.
  • Ntoumi F; Fondation Congolaise pour la Recherche Médicale, Brazzaville, Republic of Congo and Institute for Tropical Medicine, University of Tübingen, Germany.
  • Rustomjee R; Medical Research Council, Cape Town, South Africa.
  • Vilaplana C; Unitat de Tuberculosi Experimental Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i PujolEdifici Laboratoris de Recerca Can Ruti Campus, Barcelona, Spain.
  • Yeboah-Manu D; Bacteriology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
  • Rasolof V; Mycobacteria Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
  • Munderi P; Medical Research Council/Uganda Virus Research Institute, Research Unit on AIDS, Entebbe, Uganda.
  • Singh N; Inkosi Albert Luthuli Central Hospital and King DinuZulu Hospital, Durban, South Africa.
  • Aklillu E; Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Padayatchi N; Centre for AIDS Prevention Research in South Africa (CAPRISA), SAMRC CAPRISA HIV -TB pathogenesis and treatment research unit, Durban, South Africa.
  • Macete E; Centro de Investigação em Saude de Manhiça, Maputo, Mozambique.
  • Kapata N; UNZA-UCLMS Research and Training Project, University Teaching Hospital, Lusaka, Zambia.
  • Mulenga M; Tropical Diseases Research Centre, Ndola, Zambia.
  • Kibiki G; Kilimanjaro Clinical Research Institute (KCRI), Kilimanjaro, Tanzania.
  • Mfinanga S; Muhimbili Medical Research Centre National Institute for Medical Research (NIMR), Dar es Salaam, Tanzania.
  • Nyirenda T; European Developing Countries Clinical Trials Partnership (EDCTP), Cape Town, South Africa; not officially a partner of this consortium but participated in the HDT-NET Cape Town launch.
  • Maboko L; Mbeya Medical Research Centre, Mbeya, Tanzania.
  • Garcia-Basteiro A; Centro de Investigação em Saude de Manhiça, Maputo, Mozambique.
  • Rakotosamimanana N; Mycobacteria Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
  • Bates M; UNZA-UCLMS Research and Training Project, University Teaching Hospital, Lusaka, Zambia.
  • Mwaba P; UNZA-UCLMS Research and Training Project, University Teaching Hospital, Lusaka, Zambia.
  • Reither K; Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Gagneux S; Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Edwards S; Ethics and Governance, NIHR BRC at University College London Hospitals NHS Trust, London, United Kingdom.
  • Mfinanga E; Ifakara Health Institute, Bagamoyo, Tanzania.
  • Abdulla S; Ifakara Health Institute, Dar-es-Salaam, Tanzania.
  • Cardona PJ; Unitat de Tuberculosi Experimental Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i PujolEdifici Laboratoris de Recerca Can Ruti Campus, Barcelona, Spain.
  • Russell JB; Department of Internal Medicine, Connaught Hospital, College of Medicine and Allied Health Sciences, University of Sierra Leone, Sierra Leone.
  • Gant V; Department of Microbiology, University College London Hospitals NHS Foundation Trust, London, UK.
  • Noursadeghi M; 1] Division of Infection and Immunity at the University College London (UCL), London, UK and National Institute of Health Research's Biomedical Research Centre UCL Hospitals National Health Service Foundation Trust, Royal Free Campus, 2nd Floor, Rowland Hill Street, London NW3 2PF, UK. [2] Departmen
  • Elkington P; Respiratory Medicine department, Southampton University, Southampton, UK.
  • Bonnet M; Epicentre, IRD, Paris, France.
  • Menendez C; ISGlobal, Barcelona Institute for Global health, Barcelona, Spain. Immunology Unit-Laboratoire Bactériologie Virologie, Le Dantec.
  • Dieye TN; Hospital, Laboratories of the National Blood Transfusion Center, Senegal.
  • Diarra B; SEREFO (HIV/TB Research and Training CenteHIV/TB Research and Training Center, FMOS, University of STT, Bamako, Mali.
  • Maiga A; SEREFO (HIV/TB Research and Training CenteHIV/TB Research and Training Center, FMOS, University of STT, Bamako, Mali.
  • Aseffa A; Armaeur Hansen Resrach Institute (AHRI), Addis Ababa, Ethiopia.
  • Parida S; Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet and Center for Allogeneic Stem Cell Transplantation, Karolinska Hospital, Hälsovägen, SE-14186 Stockholm, Sweden.
  • Wejse C; Department of Infectious Diseases, Aarhus University, Aarhus, Denmark.
  • Petersen E; Department of Infectious Diseases, Aarhus University, Aarhus, Denmark.
  • Kaleebu P; Medical Research Council/Uganda Virus Research Institute, Research Unit on AIDS, Entebbe, Uganda.
  • Oliver M; Results UK, London, United Kingdom.
  • Craig G; School of Health Sciences, City University London, City University, London, UK.
  • Corrah T; Department of Infectious and Tropical Diseases, Northwick Park Hospital, London, UK.
  • Tientcheu L; Medical Research Council, Banjul, Gambia.
  • Antonio M; Medical Research Council, Banjul, Gambia.
  • Rao M; Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet and Center for Allogeneic Stem Cell Transplantation, Karolinska Hospital, Hälsovägen, SE-14186 Stockholm, Sweden.
Nat Rev Drug Discov ; 14(8): 511-2, 2015 Aug.
Article en En | MEDLINE | ID: mdl-26184493
ABSTRACT
The treatment of tuberculosis is based on combinations of drugs that directly target Mycobacterium tuberculosis. A new global initiative is now focusing on a complementary approach of developing adjunct host-directed therapies.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Tuberculosis / Diseño de Fármacos / Antituberculosos Idioma: En Revista: Nat Rev Drug Discov Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2015 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Tuberculosis / Diseño de Fármacos / Antituberculosos Idioma: En Revista: Nat Rev Drug Discov Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2015 Tipo del documento: Article