Synergistic effects of tacrolimus and azole antifungal compounds in fluconazole-susceptible and fluconazole-resistant Candida glabrata isolates.
Braz J Microbiol
; 46(1): 125-9, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-26221097
ABSTRACT
In vitro interaction between tacrolimus (FK506) and four azoles (fluconazole, ketoconazole, itraconazole and voriconazole) against thirty clinical isolates of both fluconazole susceptible and -resistant Candida glabrata were evaluated by the checkerboard microdilution method. Synergistic, indifferent or antagonism interactions were found for combinations of the antifungal agents and FK506. A larger synergistic effect was observed for the combinations of FK506 with itraconazole and voriconazole (43%), followed by that of the combination with ketoconazole (37%), against fluconazole-susceptible isolates. For fluconazole-resistant C. glabrata , a higher synergistic effect was obtained from FK506 combined with ketoconazole (77%), itraconazole (73%), voriconazole (63%) and fluconazole (60%). The synergisms that we observed in vitro , notably against fluconazole-resistant C. glabrata isolates, are promising and warrant further analysis of their applications in experimental in vivo studies.
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Base de datos:
MEDLINE
Asunto principal:
Azoles
/
Tacrolimus
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Candida glabrata
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Sinergismo Farmacológico
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Antifúngicos
Idioma:
En
Revista:
Braz J Microbiol
Año:
2015
Tipo del documento:
Article