A Pan-GTPase Inhibitor as a Molecular Probe.

Hong, Lin; Guo, Yuna; BasuRay, Soumik; Agola, Jacob O; Romero, Elsa; Simpson, Denise S; Schroeder, Chad E; Simons, Peter; Waller, Anna; Garcia, Matthew; Carter, Mark; Ursu, Oleg; Gouveia, Kristine; Golden, Jennifer E; Aubé, Jeffrey; Wandinger-Ness, Angela; Sklar, Larry A

Hong, Lin; Guo, Yuna; BasuRay, Soumik; Agola, Jacob O; Romero, Elsa; Simpson, Denise S; Schroeder, Chad E; Simons, Peter; Waller, Anna; Garcia, Matthew; Carter, Mark; Ursu, Oleg; Gouveia, Kristine; Golden, Jennifer E; Aubé, Jeffrey; Wandinger-Ness, Angela; Sklar, Larry A.

Afiliación

Hong L; Department of Pathology, University of New Mexico, Albuquerque, New Mexico, United States of America; University of New Mexico Center for Molecular Discovery, Albuquerque, New Mexico, United States of America.
Guo Y; Department of Pathology, University of New Mexico, Albuquerque, New Mexico, United States of America.
BasuRay S; Department of Pathology, University of New Mexico, Albuquerque, New Mexico, United States of America.
Agola JO; Department of Pathology, University of New Mexico, Albuquerque, New Mexico, United States of America.
Romero E; Department of Pathology, University of New Mexico, Albuquerque, New Mexico, United States of America.
Simpson DS; University of Kansas Specialized Chemistry Center, Lawrence, Kansas, United States of America.
Schroeder CE; University of Kansas Specialized Chemistry Center, Lawrence, Kansas, United States of America.
Simons P; Department of Pathology, University of New Mexico, Albuquerque, New Mexico, United States of America; University of New Mexico Center for Molecular Discovery, Albuquerque, New Mexico, United States of America.
Waller A; Department of Pathology, University of New Mexico, Albuquerque, New Mexico, United States of America; University of New Mexico Center for Molecular Discovery, Albuquerque, New Mexico, United States of America.
Garcia M; Department of Pathology, University of New Mexico, Albuquerque, New Mexico, United States of America; University of New Mexico Center for Molecular Discovery, Albuquerque, New Mexico, United States of America.
Carter M; Department of Pathology, University of New Mexico, Albuquerque, New Mexico, United States of America; University of New Mexico Center for Molecular Discovery, Albuquerque, New Mexico, United States of America.
Ursu O; University of New Mexico Center for Molecular Discovery, Albuquerque, New Mexico, United States of America; Cancer Research and Treatment Center, University of New Mexico, Albuquerque, New Mexico, United States of America; Department of Biochemistry and Molecular Biology, University of New Mexico, A
Gouveia K; Department of Pathology, University of New Mexico, Albuquerque, New Mexico, United States of America; University of New Mexico Center for Molecular Discovery, Albuquerque, New Mexico, United States of America.
Golden JE; University of Kansas Specialized Chemistry Center, Lawrence, Kansas, United States of America.
Aubé J; University of Kansas Specialized Chemistry Center, Lawrence, Kansas, United States of America; Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas, United States of America.
Wandinger-Ness A; Department of Pathology, University of New Mexico, Albuquerque, New Mexico, United States of America; Cancer Research and Treatment Center, University of New Mexico, Albuquerque, New Mexico, United States of America.
Sklar LA; Department of Pathology, University of New Mexico, Albuquerque, New Mexico, United States of America; University of New Mexico Center for Molecular Discovery, Albuquerque, New Mexico, United States of America; Cancer Research and Treatment Center, University of New Mexico, Albuquerque, New Mexico, U

PLoS One ; 10(8): e0134317, 2015.

Article en En | MEDLINE | ID: mdl-26247207

Asunto(s)

Inhibidores Enzimáticos/química; GTP Fosfohidrolasas/antagonistas & inhibidores; Compuestos Heterocíclicos con 2 Anillos/química; Sondas Moleculares/química; Tiourea/análogos & derivados; Apoptosis/efectos de los fármacos; Línea Celular; Supervivencia Celular/efectos de los fármacos; Inhibidores Enzimáticos/metabolismo; Inhibidores Enzimáticos/farmacología; Receptores ErbB/metabolismo; GTP Fosfohidrolasas/genética; GTP Fosfohidrolasas/metabolismo; Células HeLa; Compuestos Heterocíclicos con 2 Anillos/síntesis química; Compuestos Heterocíclicos con 2 Anillos/farmacología; Humanos; Integrinas/metabolismo; Proteína Quinasa 1 Activada por Mitógenos/metabolismo; Proteína Quinasa 3 Activada por Mitógenos/metabolismo; Sondas Moleculares/metabolismo; Sondas Moleculares/farmacología; Fosforilación/efectos de los fármacos; Unión Proteica; Transducción de Señal/efectos de los fármacos; Relación Estructura-Actividad; Tiourea/síntesis química; Tiourea/química; Tiourea/farmacología; Células U937; Proteínas de Unión al GTP rab/genética; Proteínas de Unión al GTP rab/metabolismo; Proteínas de Unión a GTP rab7; Proteínas ras/metabolismo

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Tiourea / Sondas Moleculares / Inhibidores Enzimáticos / GTP Fosfohidrolasas / Compuestos Heterocíclicos con 2 Anillos Tipo de estudio: Prognostic_studies Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article

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