Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library.

Deng, Hongfeng; Zhou, Jingye; Sundersingh, Flora S; Summerfield, Jennifer; Somers, Don; Messer, Jeffrey A; Satz, Alexander L; Ancellin, Nicolas; Arico-Muendel, Christopher C; Sargent Bedard, Katie L; Beljean, Arthur; Belyanskaya, Svetlana L; Bingham, Ryan; Smith, Sarah E; Boursier, Eric; Carter, Paul; Centrella, Paolo A; Clark, Matthew A; Chung, Chun-Wa; Davie, Christopher P; Delorey, Jennifer L; Ding, Yun; Franklin, G Joseph; Grady, LaShadric C; Herry, Kenny; Hobbs, Clare; Kollmann, Christopher S; Morgan, Barry A; Pothier Kaushansky, Laura J; Zhou, Quan

Deng, Hongfeng; Zhou, Jingye; Sundersingh, Flora S; Summerfield, Jennifer; Somers, Don; Messer, Jeffrey A; Satz, Alexander L; Ancellin, Nicolas; Arico-Muendel, Christopher C; Sargent Bedard, Katie L; Beljean, Arthur; Belyanskaya, Svetlana L; Bingham, Ryan; Smith, Sarah E; Boursier, Eric; Carter, Paul; Centrella, Paolo A; Clark, Matthew A; Chung, Chun-Wa; Davie, Christopher P; Delorey, Jennifer L; Ding, Yun; Franklin, G Joseph; Grady, LaShadric C; Herry, Kenny; Hobbs, Clare; Kollmann, Christopher S; Morgan, Barry A; Pothier Kaushansky, Laura J; Zhou, Quan.

Afiliación

Deng H; Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
Zhou J; Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
Sundersingh FS; Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
Summerfield J; Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
Somers D; Medicines Research Centre, GlaxoSmithKline , Gunnels Wood Road, Stevenage, Herts SG1 2NY, U.K.
Messer JA; Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
Satz AL; Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
Ancellin N; Centre de Recherche, GlaxoSmithKline , Les Ulis, 25,27 Avenue du Québec, 91140 Villebon sur Yvette, France.
Arico-Muendel CC; Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
Sargent Bedard KL; Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
Beljean A; Medicines Research Centre, GlaxoSmithKline , Gunnels Wood Road, Stevenage, Herts SG1 2NY, U.K.
Belyanskaya SL; Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
Bingham R; Medicines Research Centre, GlaxoSmithKline , Gunnels Wood Road, Stevenage, Herts SG1 2NY, U.K.
Smith SE; Medicines Research Centre, GlaxoSmithKline , Gunnels Wood Road, Stevenage, Herts SG1 2NY, U.K.
Boursier E; Centre de Recherche, GlaxoSmithKline , Les Ulis, 25,27 Avenue du Québec, 91140 Villebon sur Yvette, France.
Carter P; Medicines Research Centre, GlaxoSmithKline , Gunnels Wood Road, Stevenage, Herts SG1 2NY, U.K.
Centrella PA; Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
Clark MA; Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
Chung CW; Medicines Research Centre, GlaxoSmithKline , Gunnels Wood Road, Stevenage, Herts SG1 2NY, U.K.
Davie CP; Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
Delorey JL; Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
Ding Y; Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
Franklin GJ; Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
Grady LC; Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
Herry K; Centre de Recherche, GlaxoSmithKline , Les Ulis, 25,27 Avenue du Québec, 91140 Villebon sur Yvette, France.
Hobbs C; Medicines Research Centre, GlaxoSmithKline , Gunnels Wood Road, Stevenage, Herts SG1 2NY, U.K.
Kollmann CS; Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
Morgan BA; Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
Pothier Kaushansky LJ; Platform Technology and Science, GlaxoSmithKline , 830 Winter Street, Waltham, Massachusetts 02451, United States.
Zhou Q; Chemistry Department, Brandeis University , Waltham, Massachusetts 02453, United States.