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Variants on 8q24 and prostate cancer risk in Chinese population: a meta-analysis.
Ren, Xiao-Qiang; Zhang, Jian-Guo; Xin, Shi-Yong; Cheng, Tao; Li, Liang; Ren, Wei-Hua.
Afiliación
  • Ren XQ; Department of Urology, The First Affiliated Hospital of Henan University of Science and Technoloy Luoyang 471003, He'nan, China.
  • Zhang JG; Department of Urology, The First Affiliated Hospital of Henan University of Science and Technoloy Luoyang 471003, He'nan, China.
  • Xin SY; Department of Urology, The First Affiliated Hospital of Henan University of Science and Technoloy Luoyang 471003, He'nan, China.
  • Cheng T; Department of Urology, The First Affiliated Hospital of Henan University of Science and Technoloy Luoyang 471003, He'nan, China.
  • Li L; Department of Urology, The First Affiliated Hospital of Henan University of Science and Technoloy Luoyang 471003, He'nan, China.
  • Ren WH; Central Laboratory, Luoyang Central Hospital Affiliated to Zhengzhou University Luoyang 471009, He'nan, China.
Int J Clin Exp Med ; 8(6): 8561-70, 2015.
Article en En | MEDLINE | ID: mdl-26309507
Previous studies have identified 8q24 as an important region to prostate cancer (PCa) susceptibility. The aim of this study was to investigate the role of six genetic variants on 8q24 (rs1447295, A; rs6983267, G; rs6983561, C; rs7837688, T; rs10090154, T and rs16901979, A) on PCa risk in Chinese population. Online electronic databases were searched to retrieve related articles concerning the association between 8q24 variants and PCa risk in men of Chinese population published between 2000 and 2014. Odds ratio (ORs) with its 95% correspondence interval (CI) were employed to assess the strength of association. Total eleven case-control studies were screened out, including 2624 PCa patients and 2438 healthy controls. Our results showed that three risk alleles of rs1447295 A (OR=1.35, 95% CI=1.19-1.53, P<0.00001), rs6983561 C (C vs. A: OR=1.41, 95% CI=1.21-1.63, P<0.00001) and rs10090154 T (T vs. C: OR=1.48, 95% CI=1.22-1.80, P<0.00001) on8q24 were significantly associated with PCa risk in Chinese population. Furthermore, genotypes of rs1447295, AA+AC; rs6983561, CC+AC and CC; rs10090154, TT+TC; and rs16901979, AA were associated with PCa as well (P<0.01). No association was found between rs6983267, rs7837688 and PCa risk. In conclusions, variants including rs1447295, rs6983561, rs10090154 and rs16901979 on 8q24 might be associated with PCa risk in Chinese population, indicating these four variations may contribute risk to this disease. This meta-analysis was the first study to assess the role of 8q24 variants on PCa risk in Chinese population.
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Texto completo: 1 Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: Int J Clin Exp Med Año: 2015 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: Int J Clin Exp Med Año: 2015 Tipo del documento: Article