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Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives.
Deekonda, Srinivas; Wugalter, Lauren; Rankin, David; Largent-Milnes, Tally M; Davis, Peg; Wang, Yue; Bassirirad, Neemah M; Lai, Josephine; Kulkarni, Vinod; Vanderah, Todd W; Porreca, Frank; Hruby, Victor J.
Afiliación
  • Deekonda S; Department of Chemistry and Biochemistry, University of Arizona, 1306 E. University Boulevard, Tucson, AZ 85721, USA.
  • Wugalter L; Department of Chemistry and Biochemistry, University of Arizona, 1306 E. University Boulevard, Tucson, AZ 85721, USA.
  • Rankin D; Department of Pharmacology, University of Arizona, Tucson, AZ 85724, USA.
  • Largent-Milnes TM; Department of Pharmacology, University of Arizona, Tucson, AZ 85724, USA.
  • Davis P; Department of Pharmacology, University of Arizona, Tucson, AZ 85724, USA.
  • Wang Y; Department of Pharmacology, University of Arizona, Tucson, AZ 85724, USA.
  • Bassirirad NM; Department of Pharmacology, University of Arizona, Tucson, AZ 85724, USA.
  • Lai J; Department of Pharmacology, University of Arizona, Tucson, AZ 85724, USA.
  • Kulkarni V; Department of Chemistry and Biochemistry, University of Arizona, 1306 E. University Boulevard, Tucson, AZ 85721, USA.
  • Vanderah TW; Department of Pharmacology, University of Arizona, Tucson, AZ 85724, USA.
  • Porreca F; Department of Pharmacology, University of Arizona, Tucson, AZ 85724, USA.
  • Hruby VJ; Department of Chemistry and Biochemistry, University of Arizona, 1306 E. University Boulevard, Tucson, AZ 85721, USA. Electronic address: hruby@email.arizona.edu.
Bioorg Med Chem Lett ; 25(20): 4683-8, 2015 Oct 15.
Article en En | MEDLINE | ID: mdl-26323872
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Piperidinas / Encefalinas / Diseño de Fármacos / Umbral del Dolor / Receptores Opioides / Analgésicos / Contracción Muscular Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Piperidinas / Encefalinas / Diseño de Fármacos / Umbral del Dolor / Receptores Opioides / Analgésicos / Contracción Muscular Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article