Distinct Trafficking of Cell Surface and Endosomal TIM-1 to the Immune Synapse.
Traffic
; 16(11): 1193-207, 2015 Nov.
Article
en En
| MEDLINE
| ID: mdl-26332704
ABSTRACT
The T cell costimulatory molecule TIM-1 (T cell/transmembrane, mucin and immunoglobulin domain protein 1) sorts mainly to endosomes in lymphoid cells. At difference from the cell surface protein, endosomal TIM-1 translocates to the immune synapse (IS), where it can contribute to antigen-dependent T cell costimulation. TIM-1 ligands increase the amount of cell surface protein, preventing its traffic to the IS. The bipolar sorting of TIM-1 observed during IS formation is determined by differences in its subcellular location, and probably modulates antigen-driven immune responses.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Receptores Virales
/
Endosomas
/
Sinapsis
/
Glicoproteínas de Membrana
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Membrana Celular
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Movimiento Celular
Idioma:
En
Revista:
Traffic
Asunto de la revista:
FISIOLOGIA
Año:
2015
Tipo del documento:
Article