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Sulfonamide derivatives containing dihydropyrazole moieties selectively and potently inhibit MMP-2/MMP-9: Design, synthesis, inhibitory activity and 3D-QSAR analysis.
Yan, Xiao-Qiang; Wang, Zhong-Chang; Li, Zhen; Wang, Peng-Fei; Qiu, Han-Yue; Chen, Long-Wang; Lu, Xiao-Yuan; Lv, Peng-Cheng; Zhu, Hai-Liang.
Afiliación
  • Yan XQ; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
  • Wang ZC; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
  • Li Z; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
  • Wang PF; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
  • Qiu HY; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
  • Chen LW; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
  • Lu XY; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
  • Lv PC; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
  • Zhu HL; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China. Electronic address: zhuhl@nju.edu.cn.
Bioorg Med Chem Lett ; 25(20): 4664-71, 2015 Oct 15.
Article en En | MEDLINE | ID: mdl-26346367
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Pirazoles / Sulfonamidas / Diseño de Fármacos / Metaloproteinasa 2 de la Matriz / Metaloproteinasa 9 de la Matriz / Relación Estructura-Actividad Cuantitativa / Inhibidores de la Metaloproteinasa de la Matriz / Antineoplásicos Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Pirazoles / Sulfonamidas / Diseño de Fármacos / Metaloproteinasa 2 de la Matriz / Metaloproteinasa 9 de la Matriz / Relación Estructura-Actividad Cuantitativa / Inhibidores de la Metaloproteinasa de la Matriz / Antineoplásicos Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article