Invasive Aspergillosis: Epidemiology, Clinical Aspects, and Treatment.
Semin Respir Crit Care Med
; 36(5): 662-72, 2015 Oct.
Article
en En
| MEDLINE
| ID: mdl-26398533
ABSTRACT
Invasive aspergillosis remains an often fatal, difficult-to treat infection in immunocompromised patients. Patients not classically defined as immunocompromised, especially those in an intensive care unit setting, also develop invasive aspergillosis. Clinical clues suggesting angioinvasion and radiographic modalities, especially computed tomographic scans, combined with newer non-culture-based diagnostic techniques, have allowed earlier recognition of invasive aspergillosis. Although mortality remains high, it has greatly decreased over the past 15 years. Voriconazole has supplanted amphotericin B, with its various toxicities, as primary treatment for invasive aspergillosis. Combination therapy with voriconazole and an echinocandin for initial therapy, based on results from a recent controlled clinical trial, could become the standard of care in high-risk patients.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Aspergilosis
/
Antifúngicos
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Risk_factors_studies
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Screening_studies
Idioma:
En
Revista:
Semin Respir Crit Care Med
Asunto de la revista:
TERAPIA INTENSIVA
Año:
2015
Tipo del documento:
Article