Selection of natural autoreactive B cells.
Clin Exp Rheumatol
; 33(4 Suppl 92): S80-6, 2015.
Article
en En
| MEDLINE
| ID: mdl-26457505
ABSTRACT
Natural antibodies produced by CD5+ B1 B cells include anti-thymocyte autoantibody (ATA). Transgenic mice bearing the Ig-µ heavy chain of a prototypic ATA, V(H)3609Vκ21c, demonstrated a critical requirement for self-antigen in the accumulation of ATA B cells and production of high levels of serum ATA. Further work with ATA-µκ transgenic mice revealed that, while development of most B cells were blocked at an immature stage in spleen, some mature ATA B cells were present. ATA-µκ transgenic mice with varying levels of Thy-1 autoantigen showed a clear relationship between BCR crosslinking and B cell fate, with low levels generating marginal zone ATA B cells and complete antigen absence allowing maturation to follicular ATA B cells. Finally, different fates of developing ATA B cells encountering high levels self-antigen may be accounted for by variations in the response of newly formed B cells arising from foetal and adult development.
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Base de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
/
Autoinmunidad
/
Subgrupos de Linfocitos B
/
Selección Clonal Mediada por Antígenos
/
Isoanticuerpos
Idioma:
En
Revista:
Clin Exp Rheumatol
Año:
2015
Tipo del documento:
Article