Protective Effects of Molsidomine Against Cisplatin-Induced Nephrotoxicity.
Adv Clin Exp Med
; 24(4): 585-93, 2015.
Article
en En
| MEDLINE
| ID: mdl-26469102
ABSTRACT
BACKGROUND:
Cisplatin, an effective chemotherapeutic agent, is used for the treatment of several types of cancers. However, cisplatin has some severe side effects such as nephrotoxicity. On the other hand, molsidomine, a NO donor, has anti-oxidative and vasodilator effects.OBJECTIVES:
The aim of this study was to estimate the protective effects of molsidomine on cisplatin-induced nephrotoxicity. MATERIAL ANDMETHODS:
Thirty-two rats were randomly divided into 4 groups as follows (1) control; (2) received a single-dose intraperitoneal (i.p.) injection of 5 mg/kg cisplatin; (3) received single i.p. dose of molsidomine (4 mg/kg/day) for 3 consecutive days before cisplatin treatment; (4) received single i.p. dose of molsidomine (4 mg/kg/day) for 3 consecutive days. The specific biochemical markers, including antioxidants, and the histopathological alterations were evaluated.RESULTS:
Cisplatin significantly increased malondialdehyde (MDA) and myeloperoxidase (MPO) levels and decreased glutathione peroxidase (GPX) level. Molsidomine significantly decreased MPO level nearly to control level; however, its ameliorating effects on MDA, SOD, CAT and GPX did not reach to significant levels. Cisplatin-induced elevation of blood-urea-nitrogen and serum-creatinine were diminished after molsidomine administration. Cisplatin also induced severe tubular degeneration, nuclear condensation, apoptosis and scattered patchy inflammation in the histological examination. Molsidomine improved all of these histological damages.CONCLUSIONS:
In this study, the beneficial effect of molsidomine against cisplatin nephrotoxicity has been evaluated for the first time.
Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Molsidomina
/
Cisplatino
/
Sustancias Protectoras
/
Riñón
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Enfermedades Renales
Idioma:
En
Revista:
Adv Clin Exp Med
Año:
2015
Tipo del documento:
Article