Global and Local Conformation of Human IgG Antibody Variants Rationalizes Loss of Thermodynamic Stability.

Edgeworth, Matthew J; Phillips, Jonathan J; Lowe, David C; Kippen, Alistair D; Higazi, Daniel R; Scrivens, James H

Edgeworth, Matthew J; Phillips, Jonathan J; Lowe, David C; Kippen, Alistair D; Higazi, Daniel R; Scrivens, James H.

Afiliación

Edgeworth MJ; MedImmune, Sir Aaron Klug Building, Granta Park, Cambridge, CB21 6GH (UK).
Phillips JJ; Department of Chemical Engineering and Biotechnology, University of Cambridge, Pembroke Street, Cambridge, CB2 3RA (UK).
Lowe DC; MedImmune, Sir Aaron Klug Building, Granta Park, Cambridge, CB21 6GH (UK).
Kippen AD; MedImmune, Sir Aaron Klug Building, Granta Park, Cambridge, CB21 6GH (UK).
Higazi DR; MedImmune, Sir Aaron Klug Building, Granta Park, Cambridge, CB21 6GH (UK).
Scrivens JH; School of Life Sciences, University of Warwick, Coventry, CV4 7AL (UK). Jim.Scrivens@gmail.com.

Angew Chem Int Ed Engl ; 54(50): 15156-9, 2015 Dec 07.

Article en En | MEDLINE | ID: mdl-26482340

Asunto(s)

Anticuerpos Monoclonales/química; Inmunoglobulina G/química; Termodinámica; Medición de Intercambio de Deuterio; Humanos; Espectrometría de Masas; Conformación Proteica

Palabras clave

antibodies; hydrogen exchange; immunoglobulin; ion mobility; mass spectrometry

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Termodinámica / Inmunoglobulina G / Anticuerpos Monoclonales Idioma: En Revista: Angew Chem Int Ed Engl Año: 2015 Tipo del documento: Article

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