Intervention to improve the quality of antimicrobial prescribing for urinary tract infection: a cluster randomized trial.
CMAJ
; 188(2): 108-115, 2016 Feb 02.
Article
en En
| MEDLINE
| ID: mdl-26573754
ABSTRACT
BACKGROUND:
Overuse of antimicrobial therapy in the community adds to the global spread of antimicrobial resistance, which is jeopardizing the treatment of common infections.METHODS:
We designed a cluster randomized complex intervention to improve antimicrobial prescribing for urinary tract infection in Irish general practice. During a 3-month baseline period, all practices received a workshop to promote consultation coding for urinary tract infections. Practices in intervention arms A and B received a second workshop with information on antimicrobial prescribing guidelines and a practice audit report (baseline data). Practices in intervention arm B received additional evidence on delayed prescribing of antimicrobials for suspected urinary tract infection. A reminder integrated into the patient management software suggested first-line treatment and, for practices in arm B, delayed prescribing. Over the 6-month intervention, practices in arms A and B received monthly audit reports of antimicrobial prescribing.RESULTS:
The proportion of antimicrobial prescribing according to guidelines for urinary tract infection increased in arms A and B relative to control (adjusted overall odds ratio [OR] 2.3, 95% confidence interval [CI] 1.7 to 3.2; arm A adjusted OR 2.7, 95% CI 1.8 to 4.1; arm B adjusted OR 2.0, 95% CI 1.3 to 3.0). An unintended increase in antimicrobial prescribing was observed in the intervention arms relative to control (arm A adjusted OR 2.2, 95% CI 1.2 to 4.0; arm B adjusted OR 1.4, 95% CI 0.9 to 2.1). Improvements in guideline-based prescribing were sustained at 5 months after the intervention.INTERPRETATION:
A complex intervention, including audit reports and reminders, improved the quality of prescribing for urinary tract infection in Irish general practice. TRIAL REGISTRATION ClinicalTrials.gov, no. NCT01913860.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Infecciones Urinarias
/
Pautas de la Práctica en Medicina
/
Adhesión a Directriz
/
Prescripción Inadecuada
/
Medicina General
/
Antibacterianos
Tipo de estudio:
Clinical_trials
/
Guideline
/
Prognostic_studies
País/Región como asunto:
Europa
Idioma:
En
Revista:
CMAJ
Asunto de la revista:
MEDICINA
Año:
2016
Tipo del documento:
Article