An unexpected Bromolactamization of Olefinic Amides Using a Three-Component Co-catalyst System.
J Org Chem
; 81(2): 545-52, 2016 Jan 15.
Article
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| MEDLINE
| ID: mdl-26679219
ABSTRACT
Reaction between (N,N-dimethylamino)pyridine and isocyanate unexpectedly produced a three-component mixture. By using this mixture as an unprecedented three-component catalyst system, a facile and selective bromolactamization of olefinic amides has been developed. The protocol confers enhanced selectivity of N- over O-cyclization, leading to the formation of a structurally diverse range of lactams including both small and medium ring sizes.
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MEDLINE
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J Org Chem
Año:
2016
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Article