Anti-Inflammatory Effects of Ginsenoside-Rh2 Inhibits LPS-Induced Activation of Microglia and Overproduction of Inflammatory Mediators Via Modulation of TGF-ß1/Smad Pathway.
Neurochem Res
; 41(5): 951-7, 2016 May.
Article
en En
| MEDLINE
| ID: mdl-26738987
ABSTRACT
Microglia activation plays an important role in neuroinflammation and contributes to several neurological disorders. Hence, inhibition of both microglia activation and pro-inflammatory cytokines may lead to the effective treatment of neurodegenerative diseases. In this study, we found that GRh2 inhibited the inflammatory response to lipopolysaccharide (LPS) and prevented the LPS-induced neurotoxicity in microglia cells. GRh2 significantly decreased the generation of nitric oxide production, and tumor necrosis factor-α, interleukin (IL)-6, IL-1ß, cyclooxygenase-2 and inducible nitric oxide synthase in LPS-induced activated microglia cells. Furthermore, GRh2 (20 and 50 µM) significantly increased TGF-ß1 expression and reduced the expression of Smad. These results suggest that GRh2 effectively inhibits microglia activation and production of pro-inflammatory cytokines via modulating the TGF-ß1/Smad pathway.
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Base de datos:
MEDLINE
Asunto principal:
Lipopolisacáridos
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Microglía
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Fármacos Neuroprotectores
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Mediadores de Inflamación
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Ginsenósidos
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Proteínas Smad
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Factor de Crecimiento Transformador beta1
Idioma:
En
Revista:
Neurochem Res
Año:
2016
Tipo del documento:
Article