A highly immunogenic vaccine against A/H7N9 influenza virus.
Vaccine
; 34(6): 744-9, 2016 Feb 03.
Article
en En
| MEDLINE
| ID: mdl-26765287
ABSTRACT
Since the first case of human infection in March 2013, continued reports of H7N9 cases highlight a potential pandemic threat. Highly immunogenic vaccines to this virus are urgently needed to protect vulnerable populations who lack protective immunity. In this study, an egg- and adjuvant-independent adenoviral vector-based, hemagglutinin H7 subtype influenza vaccine (HAd-H7HA) demonstrated enhanced cell-mediated immunity as well as serum antibody responses in a mouse model. Most importantly, this vaccine provided complete protection against homologous A/H7N9 viral challenge suggesting its potential utility as a pandemic vaccine.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Vacunas contra la Influenza
/
Infecciones por Orthomyxoviridae
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Glicoproteínas Hemaglutininas del Virus de la Influenza
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Subtipo H7N9 del Virus de la Influenza A
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Inmunidad Celular
Idioma:
En
Revista:
Vaccine
Año:
2016
Tipo del documento:
Article