Your browser doesn't support javascript.
loading
A highly immunogenic vaccine against A/H7N9 influenza virus.
Cao, Weiping; Liepkalns, Justine S; Hassan, Ahmed O; Kamal, Ram P; Hofstetter, Amelia R; Amoah, Samuel; Kim, Jin Hyang; Reber, Adrian J; Stevens, James; Katz, Jacqueline M; Gangappa, Shivaprakash; York, Ian A; Mittal, Suresh K; Sambhara, Suryaprakash.
Afiliación
  • Cao W; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA.
  • Liepkalns JS; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA.
  • Hassan AO; Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907, USA.
  • Kamal RP; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA; Battelle Memorial Institute, Atlanta, GA, USA.
  • Hofstetter AR; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.
  • Amoah S; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA; Battelle Memorial Institute, Atlanta, GA, USA.
  • Kim JH; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA.
  • Reber AJ; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA.
  • Stevens J; Virus, Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA.
  • Katz JM; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA.
  • Gangappa S; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA.
  • York IA; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA.
  • Mittal SK; Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907, USA. Electronic address: mittal@purdue.edu.
  • Sambhara S; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA. Electronic address: zao1@cdc.gov.
Vaccine ; 34(6): 744-9, 2016 Feb 03.
Article en En | MEDLINE | ID: mdl-26765287
ABSTRACT
Since the first case of human infection in March 2013, continued reports of H7N9 cases highlight a potential pandemic threat. Highly immunogenic vaccines to this virus are urgently needed to protect vulnerable populations who lack protective immunity. In this study, an egg- and adjuvant-independent adenoviral vector-based, hemagglutinin H7 subtype influenza vaccine (HAd-H7HA) demonstrated enhanced cell-mediated immunity as well as serum antibody responses in a mouse model. Most importantly, this vaccine provided complete protection against homologous A/H7N9 viral challenge suggesting its potential utility as a pandemic vaccine.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Vacunas contra la Influenza / Infecciones por Orthomyxoviridae / Glicoproteínas Hemaglutininas del Virus de la Influenza / Subtipo H7N9 del Virus de la Influenza A / Inmunidad Celular Idioma: En Revista: Vaccine Año: 2016 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Vacunas contra la Influenza / Infecciones por Orthomyxoviridae / Glicoproteínas Hemaglutininas del Virus de la Influenza / Subtipo H7N9 del Virus de la Influenza A / Inmunidad Celular Idioma: En Revista: Vaccine Año: 2016 Tipo del documento: Article