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Antimicrobial activity of a quaternized BODIPY against Staphylococcus strains.
Aydin Tekdas, Duygu; Viswanathan, Geetha; Zehra Topal, Sevinc; Looi, Chung Yeng; Wong, Won Fen; Min Yi Tan, Grace; Zorlu, Yunus; Gürek, Ayse Gül; Lee, Hong Boon; Dumoulin, Fabienne.
Afiliación
  • Aydin Tekdas D; Gebze Technical University, Department of Chemistry, P.O Box 141, 41400 Gebze Kocaeli, Turkey. gurek@gtu.edu.tr fdumoulin@gtu.edu.tr.
  • Viswanathan G; Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. hongboonlee@um.edu.my.
  • Zehra Topal S; Gebze Technical University, Department of Chemistry, P.O Box 141, 41400 Gebze Kocaeli, Turkey. gurek@gtu.edu.tr fdumoulin@gtu.edu.tr.
  • Looi CY; Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
  • Wong WF; Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
  • Min Yi Tan G; Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
  • Zorlu Y; Gebze Technical University, Department of Chemistry, P.O Box 141, 41400 Gebze Kocaeli, Turkey. gurek@gtu.edu.tr fdumoulin@gtu.edu.tr.
  • Gürek AG; Gebze Technical University, Department of Chemistry, P.O Box 141, 41400 Gebze Kocaeli, Turkey. gurek@gtu.edu.tr fdumoulin@gtu.edu.tr.
  • Lee HB; Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. hongboonlee@um.edu.my.
  • Dumoulin F; Gebze Technical University, Department of Chemistry, P.O Box 141, 41400 Gebze Kocaeli, Turkey. gurek@gtu.edu.tr fdumoulin@gtu.edu.tr.
Org Biomol Chem ; 14(9): 2665-70, 2016 Mar 07.
Article en En | MEDLINE | ID: mdl-26831779
A novel BODIPY derivative was designed for biomedical applications. Its mono-quaternized structure ensured its water-solubility and suitable amphiphilicity. Showing no singlet oxygen generation to avoid damage to healthy cells, this new derivative proved to be an extremely promising antimicrobial agent, with activity equal or superior to ampicillin against MRS Staphylococcus strains with no short-term resistance issue. Its activity against MSS Staphylococcus strains was largely superior to those of ampicillin and reached the activity of vancomycin against MSS S. epidermidis. This latter result is in particular extremely promising for the treatment of hospital-acquired infections. Also the fluorescence properties of BODIPY allowed imaging of the uptake.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Staphylococcus / Compuestos de Boro / Antibacterianos Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Staphylococcus / Compuestos de Boro / Antibacterianos Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article