Trends and Variations in the Use of Inhaled Nitric Oxide in Preterm Infants in Canadian Neonatal Intensive Care Units.
Am J Perinatol
; 33(7): 715-22, 2016 06.
Article
en En
| MEDLINE
| ID: mdl-26890441
ABSTRACT
Objective To determine the proportion of infants who receive inhaled nitric oxide (iNO), and to characterize the variations in its use by gestational age (GA) and center in infants <34 weeks' gestation. Design Retrospective analysis was performed in infants born at <34 weeks' gestation and admitted to neonatal intensive care units participating in the Canadian Neonatal Network between January 2010 and December 2013. Results Of 19,525 infants, 831 (4.2%) received iNO. A total of 369 infants (44%) received iNO during the first 2 days after birth. The proportion of neonates who received iNO in the 22 to 25, 26 to 29, and 30 to 33 weeks' GA groups was 16.1, 6.0, and 1.3%, respectively. Infants in whom iNO was initiated in the first 2 days of age received it for a shorter duration (median, 3 days; interquartile range [IQR], 2-5) as compared with those who started after 2 days (median, 5 days; IQR, 2-11). The use of iNO varied by center, ranging from 0 to 15.5% (p < 0.001). Conclusion Out of every 25 infants born at <34 weeks' gestation in Canada received iNO, with the highest rate of use in infants born at lower gestation. Further research to identify reasoning, efficacy, and safety of iNO in preterm infants is warranted.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Recien Nacido Prematuro
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Unidades de Cuidado Intensivo Neonatal
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Enfermedades del Prematuro
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Óxido Nítrico
Tipo de estudio:
Guideline
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Observational_studies
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Prognostic_studies
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Am J Perinatol
Año:
2016
Tipo del documento:
Article