Inhibition of Orai1 Store-Operated Calcium Channel Prevents Foam Cell Formation and Atherosclerosis.

Liang, Si-Jia; Zeng, De-Yi; Mai, Xiao-Yi; Shang, Jin-Yan; Wu, Qian-Qian; Yuan, Jia-Ni; Yu, Bei-Xin; Zhou, Ping; Zhang, Fei-Ran; Liu, Ying-Ying; Lv, Xiao-Fei; Liu, Jie; Ou, Jing-Song; Qian, Jie-Sheng; Zhou, Jia-Guo

Liang, Si-Jia; Zeng, De-Yi; Mai, Xiao-Yi; Shang, Jin-Yan; Wu, Qian-Qian; Yuan, Jia-Ni; Yu, Bei-Xin; Zhou, Ping; Zhang, Fei-Ran; Liu, Ying-Ying; Lv, Xiao-Fei; Liu, Jie; Ou, Jing-Song; Qian, Jie-Sheng; Zhou, Jia-Guo.

Afiliación

Liang SJ; From the Department of Pharmacology, Cardiac and Cerebrovascular Research Center (S.-J.L., D.-Y.Z., X.-Y.M., J.-Y.S., Q.-Q.W., J.-N.Y., B.-X.Y., F.-R.Z., Y.-Y.L., X.-F.L., J.L., J.-G.Z.) and Guangdong Province Key Laboratory of Brain Function and Disease (J.-G.Z.), Zhongshan School of Medicine, Divi
Zeng DY; From the Department of Pharmacology, Cardiac and Cerebrovascular Research Center (S.-J.L., D.-Y.Z., X.-Y.M., J.-Y.S., Q.-Q.W., J.-N.Y., B.-X.Y., F.-R.Z., Y.-Y.L., X.-F.L., J.L., J.-G.Z.) and Guangdong Province Key Laboratory of Brain Function and Disease (J.-G.Z.), Zhongshan School of Medicine, Divi
Mai XY; From the Department of Pharmacology, Cardiac and Cerebrovascular Research Center (S.-J.L., D.-Y.Z., X.-Y.M., J.-Y.S., Q.-Q.W., J.-N.Y., B.-X.Y., F.-R.Z., Y.-Y.L., X.-F.L., J.L., J.-G.Z.) and Guangdong Province Key Laboratory of Brain Function and Disease (J.-G.Z.), Zhongshan School of Medicine, Divi
Shang JY; From the Department of Pharmacology, Cardiac and Cerebrovascular Research Center (S.-J.L., D.-Y.Z., X.-Y.M., J.-Y.S., Q.-Q.W., J.-N.Y., B.-X.Y., F.-R.Z., Y.-Y.L., X.-F.L., J.L., J.-G.Z.) and Guangdong Province Key Laboratory of Brain Function and Disease (J.-G.Z.), Zhongshan School of Medicine, Divi
Wu QQ; From the Department of Pharmacology, Cardiac and Cerebrovascular Research Center (S.-J.L., D.-Y.Z., X.-Y.M., J.-Y.S., Q.-Q.W., J.-N.Y., B.-X.Y., F.-R.Z., Y.-Y.L., X.-F.L., J.L., J.-G.Z.) and Guangdong Province Key Laboratory of Brain Function and Disease (J.-G.Z.), Zhongshan School of Medicine, Divi
Yuan JN; From the Department of Pharmacology, Cardiac and Cerebrovascular Research Center (S.-J.L., D.-Y.Z., X.-Y.M., J.-Y.S., Q.-Q.W., J.-N.Y., B.-X.Y., F.-R.Z., Y.-Y.L., X.-F.L., J.L., J.-G.Z.) and Guangdong Province Key Laboratory of Brain Function and Disease (J.-G.Z.), Zhongshan School of Medicine, Divi
Yu BX; From the Department of Pharmacology, Cardiac and Cerebrovascular Research Center (S.-J.L., D.-Y.Z., X.-Y.M., J.-Y.S., Q.-Q.W., J.-N.Y., B.-X.Y., F.-R.Z., Y.-Y.L., X.-F.L., J.L., J.-G.Z.) and Guangdong Province Key Laboratory of Brain Function and Disease (J.-G.Z.), Zhongshan School of Medicine, Divi
Zhou P; From the Department of Pharmacology, Cardiac and Cerebrovascular Research Center (S.-J.L., D.-Y.Z., X.-Y.M., J.-Y.S., Q.-Q.W., J.-N.Y., B.-X.Y., F.-R.Z., Y.-Y.L., X.-F.L., J.L., J.-G.Z.) and Guangdong Province Key Laboratory of Brain Function and Disease (J.-G.Z.), Zhongshan School of Medicine, Divi
Zhang FR; From the Department of Pharmacology, Cardiac and Cerebrovascular Research Center (S.-J.L., D.-Y.Z., X.-Y.M., J.-Y.S., Q.-Q.W., J.-N.Y., B.-X.Y., F.-R.Z., Y.-Y.L., X.-F.L., J.L., J.-G.Z.) and Guangdong Province Key Laboratory of Brain Function and Disease (J.-G.Z.), Zhongshan School of Medicine, Divi
Liu YY; From the Department of Pharmacology, Cardiac and Cerebrovascular Research Center (S.-J.L., D.-Y.Z., X.-Y.M., J.-Y.S., Q.-Q.W., J.-N.Y., B.-X.Y., F.-R.Z., Y.-Y.L., X.-F.L., J.L., J.-G.Z.) and Guangdong Province Key Laboratory of Brain Function and Disease (J.-G.Z.), Zhongshan School of Medicine, Divi
Lv XF; From the Department of Pharmacology, Cardiac and Cerebrovascular Research Center (S.-J.L., D.-Y.Z., X.-Y.M., J.-Y.S., Q.-Q.W., J.-N.Y., B.-X.Y., F.-R.Z., Y.-Y.L., X.-F.L., J.L., J.-G.Z.) and Guangdong Province Key Laboratory of Brain Function and Disease (J.-G.Z.), Zhongshan School of Medicine, Divi
Liu J; From the Department of Pharmacology, Cardiac and Cerebrovascular Research Center (S.-J.L., D.-Y.Z., X.-Y.M., J.-Y.S., Q.-Q.W., J.-N.Y., B.-X.Y., F.-R.Z., Y.-Y.L., X.-F.L., J.L., J.-G.Z.) and Guangdong Province Key Laboratory of Brain Function and Disease (J.-G.Z.), Zhongshan School of Medicine, Divi
Ou JS; From the Department of Pharmacology, Cardiac and Cerebrovascular Research Center (S.-J.L., D.-Y.Z., X.-Y.M., J.-Y.S., Q.-Q.W., J.-N.Y., B.-X.Y., F.-R.Z., Y.-Y.L., X.-F.L., J.L., J.-G.Z.) and Guangdong Province Key Laboratory of Brain Function and Disease (J.-G.Z.), Zhongshan School of Medicine, Divi
Qian JS; From the Department of Pharmacology, Cardiac and Cerebrovascular Research Center (S.-J.L., D.-Y.Z., X.-Y.M., J.-Y.S., Q.-Q.W., J.-N.Y., B.-X.Y., F.-R.Z., Y.-Y.L., X.-F.L., J.L., J.-G.Z.) and Guangdong Province Key Laboratory of Brain Function and Disease (J.-G.Z.), Zhongshan School of Medicine, Divi
Zhou JG; From the Department of Pharmacology, Cardiac and Cerebrovascular Research Center (S.-J.L., D.-Y.Z., X.-Y.M., J.-Y.S., Q.-Q.W., J.-N.Y., B.-X.Y., F.-R.Z., Y.-Y.L., X.-F.L., J.L., J.-G.Z.) and Guangdong Province Key Laboratory of Brain Function and Disease (J.-G.Z.), Zhongshan School of Medicine, Divi

Arterioscler Thromb Vasc Biol ; 36(4): 618-28, 2016 Apr.

Article en En | MEDLINE | ID: mdl-26916730

Asunto(s)

Anticolesterolemiantes/farmacología; Aorta/efectos de los fármacos; Enfermedades de la Aorta/prevención & control; Aterosclerosis/prevención & control; Bloqueadores de los Canales de Calcio/farmacología; Canales de Calcio/efectos de los fármacos; Calcio/metabolismo; Colesterol/metabolismo; Células Espumosas/efectos de los fármacos; Macrófagos Peritoneales/efectos de los fármacos; Animales; Aorta/metabolismo; Aorta/patología; Enfermedades de la Aorta/genética; Enfermedades de la Aorta/metabolismo; Enfermedades de la Aorta/patología; Apolipoproteínas E/deficiencia; Apolipoproteínas E/genética; Apoptosis/efectos de los fármacos; Aterosclerosis/genética; Aterosclerosis/metabolismo; Aterosclerosis/patología; Calcineurina/metabolismo; Canales de Calcio/genética; Canales de Calcio/metabolismo; Quelantes del Calcio/farmacología; Señalización del Calcio/efectos de los fármacos; Línea Celular Tumoral; Modelos Animales de Enfermedad; Relación Dosis-Respuesta a Droga; Células Espumosas/metabolismo; Células Espumosas/patología; Humanos; Mediadores de Inflamación/metabolismo; Proteínas Quinasas JNK Activadas por Mitógenos/metabolismo; Lipoproteínas LDL/farmacología; MAP Quinasa Quinasa Quinasa 5/metabolismo; Macrófagos Peritoneales/metabolismo; Macrófagos Peritoneales/patología; Ratones Noqueados; Proteína ORAI1; Placa Aterosclerótica; Interferencia de ARN; Receptores Depuradores de Clase A/metabolismo; Factores de Tiempo; Transfección; Proteínas Quinasas p38 Activadas por Mitógenos/metabolismo

Palabras clave

apoptosis; atherosclerosis; foam cells; inflammation; monocytes

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Aorta / Enfermedades de la Aorta / Bloqueadores de los Canales de Calcio / Canales de Calcio / Calcio / Colesterol / Macrófagos Peritoneales / Aterosclerosis / Células Espumosas / Anticolesterolemiantes Tipo de estudio: Prognostic_studies Idioma: En Revista: Arterioscler Thromb Vasc Biol Asunto de la revista: ANGIOLOGIA Año: 2016 Tipo del documento: Article

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