T follicular helper (Tfh ) cells in normal immune responses and in allergic disorders.
Allergy
; 71(8): 1086-94, 2016 08.
Article
en En
| MEDLINE
| ID: mdl-26970097
ABSTRACT
Follicular helper T cells (Tfh ) are located within germinal centers of lymph nodes. Cognate interaction between Tfh , B cells, and IL-21 drives B cells to proliferate and differentiate into plasma cells thereby leading to antibody production. Tfh cells and IL-21 are involved in infectious and autoimmune diseases, immunodeficiencies, vaccination, and cancer. Human peripheral blood CXCR5(+) CD4(+) T cells comprise different subsets of Tfh -like cells. Despite the importance of the IgE response in the pathogenesis of allergic disorders, little is known about the role of follicular and blood Tfh cells and IL-21 in human and experimental allergic disease. Here, we review recent advances regarding the phenotypic and functional characteristics of both follicular and blood Tfh cells and of the IL-21/IL-21R system in the context of allergic disorders.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T Colaboradores-Inductores
/
Fenómenos del Sistema Inmunológico
/
Hipersensibilidad
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Allergy
Año:
2016
Tipo del documento:
Article