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Cost-Effectiveness of Blood Donation Screening for Trypanosoma cruzi in Mexico.
Sánchez-González, Gilberto; Figueroa-Lara, Alejandro; Elizondo-Cano, Miguel; Wilson, Leslie; Novelo-Garza, Barbara; Valiente-Banuet, Leopoldo; Ramsey, Janine M.
Afiliación
  • Sánchez-González G; Immunology Division, National Institute of Public Health, Cuernavaca, Mexico.
  • Figueroa-Lara A; Escuela Militar de Graduados de Sanidad, Mexico City, Mexico.
  • Elizondo-Cano M; Division of Innovation and Technology Management, Mexican Social Security Institute, Mexico City, Mexico.
  • Wilson L; Health Economics Division, National Institute of Public Health, Cuernavaca, Mexico.
  • Novelo-Garza B; Departments of Medicine and Pharmacy, University of California, San Francisco, San Francisco, California, United States of America.
  • Valiente-Banuet L; Medical Infrastructure Planning Coordination, Mexican Social Security Institute, Mexico City, Mexico.
  • Ramsey JM; Centro de Ciencias de la Complejidad C3, UNAM, Mexico City, Mexico.
PLoS Negl Trop Dis ; 10(3): e0004528, 2016 Mar.
Article en En | MEDLINE | ID: mdl-27002523
ABSTRACT
An estimated 2 million inhabitants are infected with Chagas disease in Mexico, with highest prevalence coinciding with highest demographic density in the southern half of the country. After vector-borne transmission, Trypanosoma cruzi is principally transmitted to humans via blood transfusion. Despite initiation of serological screening of blood donations or donors for T. cruzi since 1990 in most Latin American countries, Mexico only finally included mandatory serological screening nationwide in official Norms in 2012. Most recent regulatory changes and segmented blood services in Mexico may affect compliance of mandatory screening guidelines. The objective of this study was to calculate the incremental cost-effectiveness ratio for total compliance of current guidelines from both Mexican primary healthcare and regular salaried worker health service institutions the Secretary of Health and the Mexican Institute for Social Security. We developed a bi-modular model to analyze compliance using a decision tree for the most common screening algorithms for each health institution, and a Markov transition model for the natural history of illness and care. The incremental cost effectiveness ratio based on life-years gained is US$ 383 for the Secretary of Health, while the cost for an additional life-year gained is US$ 463 for the Social Security Institute. The results of the present study suggest that due to incomplete compliance of Mexico's national legislation during 2013 and 2014, the MoH has failed to confirm 15,162 T. cruzi infections, has not prevented 2,347 avoidable infections, and has lost 333,483 life-years. Although there is a vast difference in T. cruzi prevalence between Bolivia and Mexico, Bolivia established mandatory blood screening for T.cruzi in 1996 and until 2002 detected and discarded 11,489 T. cruzi -infected blood units and prevented 2,879 potential infections with their transfusion blood screening program. In the first two years of Mexico's mandated program, the two primary institutions failed to prevent due to incomplete compliance more potential infections than those gained from the first five years of Bolivia's program. Full regulatory compliance should be clearly understood as mandatory for the sake of blood security, and its monitoring and analysis in Mexico should be part of the health authority's responsibility.
Asunto(s)

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Trypanosoma cruzi / Pruebas Serológicas / Enfermedad de Chagas Tipo de estudio: Diagnostic_studies / Health_economic_evaluation / Prognostic_studies / Risk_factors_studies / Screening_studies País/Región como asunto: Mexico Idioma: En Revista: PLoS Negl Trop Dis Asunto de la revista: MEDICINA TROPICAL Año: 2016 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Trypanosoma cruzi / Pruebas Serológicas / Enfermedad de Chagas Tipo de estudio: Diagnostic_studies / Health_economic_evaluation / Prognostic_studies / Risk_factors_studies / Screening_studies País/Región como asunto: Mexico Idioma: En Revista: PLoS Negl Trop Dis Asunto de la revista: MEDICINA TROPICAL Año: 2016 Tipo del documento: Article