Glucocerebrosidase Deficiency in Drosophila Results in &#945;-Synuclein-Independent Protein Aggregation and Neurodegeneration.

Davis, Marie Y; Trinh, Kien; Thomas, Ruth E; Yu, Selina; Germanos, Alexandre A; Whitley, Brittany N; Sardi, Sergio Pablo; Montine, Thomas J; Pallanck, Leo J

Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration.

Davis, Marie Y; Trinh, Kien; Thomas, Ruth E; Yu, Selina; Germanos, Alexandre A; Whitley, Brittany N; Sardi, Sergio Pablo; Montine, Thomas J; Pallanck, Leo J.

Afiliación

Davis MY; Department of Neurology, University of Washington, Seattle, Washington, United States of America.
Trinh K; Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America.
Thomas RE; Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America.
Yu S; Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America.
Germanos AA; Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America.
Whitley BN; Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America.
Sardi SP; Department of Biochemistry, University of Washington, Seattle, Washington, United States of America.
Montine TJ; Neuroscience, Rare Diseases Research Unit, Sanofi Genzyme, Framingham, Massachusetts, United States of America.
Pallanck LJ; Department of Pathology, University of Washington, Seattle, Washington, United States of America.

PLoS Genet ; 12(3): e1005944, 2016 Mar.

Article en En | MEDLINE | ID: mdl-27019408

Asunto(s)

Enfermedad de Gaucher/genética; Glucosilceramidasa/genética; Degeneración Nerviosa/genética; Enfermedad de Parkinson/genética; alfa-Sinucleína/genética; Animales; Neuronas Dopaminérgicas/metabolismo; Neuronas Dopaminérgicas/patología; Drosophila melanogaster; Enfermedad de Gaucher/metabolismo; Enfermedad de Gaucher/patología; Glucosilceramidasa/metabolismo; Humanos; Lisosomas/genética; Lisosomas/patología; Degeneración Nerviosa/patología; Enfermedad de Parkinson/metabolismo; Enfermedad de Parkinson/patología; Fenotipo; Agregación Patológica de Proteínas

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Alfa-Sinucleína / Enfermedad de Gaucher / Glucosilceramidasa / Degeneración Nerviosa Tipo de estudio: Risk_factors_studies Idioma: En Revista: PLoS Genet Asunto de la revista: GENETICA Año: 2016 Tipo del documento: Article

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