Statistical analysis of data from limiting dilution cloning to assess monoclonality in generating manufacturing cell lines.

Quiroz, Jorge; Tsao, Yung-Shyeng

Quiroz, Jorge; Tsao, Yung-Shyeng.

Afiliación

Quiroz J; BARDS, Research CMC Statistics, Merck Research Laboratories, Kenilworth, NJ, 07033, USA.
Tsao YS; Department of Bioprocess Technology Expression, Biologics and Vaccines, Merck Research Laboratories, Kenilworth, NJ, 07033, USA.

Biotechnol Prog ; 32(4): 1061-8, 2016 07 08.

Article en En | MEDLINE | ID: mdl-27111698

Asunto(s)

Células Clonales/citología; Modelos Estadísticos; Línea Celular; Humanos

Palabras clave

Poisson distribution; limiting dilution cloning; manufacturing cell lines; monoclonality in one round of subcloning; monoclonality in two consecutive subclonings; recombinant protein production

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Modelos Estadísticos / Células Clonales Tipo de estudio: Risk_factors_studies Idioma: En Revista: Biotechnol Prog Asunto de la revista: BIOTECNOLOGIA Año: 2016 Tipo del documento: Article

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