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Alphaherpesvirus DNA replication in dissociated human trigeminal ganglia.
Cohrs, Randall J; Badani, Hussain; Bos, Nathan; Scianna, Charles; Hoskins, Ian; Baird, Nicholas L; Gilden, Don.
Afiliación
  • Cohrs RJ; Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Mail Stop B182, Aurora, CO, 80045, USA. randall.cohrs@ucdenver.edu.
  • Badani H; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, 80045, USA. randall.cohrs@ucdenver.edu.
  • Bos N; Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Mail Stop B182, Aurora, CO, 80045, USA.
  • Scianna C; Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Mail Stop B182, Aurora, CO, 80045, USA.
  • Hoskins I; Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Mail Stop B182, Aurora, CO, 80045, USA.
  • Baird NL; Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Mail Stop B182, Aurora, CO, 80045, USA.
  • Gilden D; Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Mail Stop B182, Aurora, CO, 80045, USA.
J Neurovirol ; 22(5): 688-694, 2016 10.
Article en En | MEDLINE | ID: mdl-27173396
ABSTRACT
Analysis of the frequency and PCR-quantifiable abundance of herpes simplex virus type 1 (HSV-1) and varicella zoster virus (VZV) DNA in multiple biological replicates of cells from dissociated randomly distributed human trigeminal ganglia (TG) of four subjects revealed an increase in both parameters and in both viruses during 5 days of culture, with no further change by 10 days. Dissociated TG provides a platform to analyze initiation of latent virus DNA replication within 5 days of culture.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Activación Viral / Replicación Viral / Ganglio del Trigémino / Herpesvirus Humano 1 / Herpesvirus Humano 3 / Replicación del ADN Idioma: En Revista: J Neurovirol Asunto de la revista: NEUROLOGIA / VIROLOGIA Año: 2016 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Activación Viral / Replicación Viral / Ganglio del Trigémino / Herpesvirus Humano 1 / Herpesvirus Humano 3 / Replicación del ADN Idioma: En Revista: J Neurovirol Asunto de la revista: NEUROLOGIA / VIROLOGIA Año: 2016 Tipo del documento: Article