Design, synthesis of 2,3-disubstitued 4(3H)-quinazolinone derivatives as anti-inflammatory and analgesic agents: COX-1/2 inhibitory activities and molecular docking studies.

Abdel-Aziz, Alaa A-M; Abou-Zeid, Laila A; ElTahir, Kamal Eldin H; Mohamed, Menshawy A; Abu El-Enin, Mohamed A; El-Azab, Adel S

Abdel-Aziz, Alaa A-M; Abou-Zeid, Laila A; ElTahir, Kamal Eldin H; Mohamed, Menshawy A; Abu El-Enin, Mohamed A; El-Azab, Adel S.

Afiliación

Abdel-Aziz AA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. Electronic address: alaa_moenes@yahoo.com.
Abou-Zeid LA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
ElTahir KE; Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Mohamed MA; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, AlKharj, Saudi Arabia; Department of Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Abu El-Enin MA; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
El-Azab AS; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia; Department of Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt. Electronic address: adelazaba@yahoo.com.

Bioorg Med Chem ; 24(16): 3818-28, 2016 08 15.

Article en En | MEDLINE | ID: mdl-27344214

Asunto(s)

Analgésicos/farmacología; Antiinflamatorios/farmacología; Inhibidores de la Ciclooxigenasa/farmacología; Quinazolinonas/química; Quinazolinonas/farmacología; Analgésicos/síntesis química; Analgésicos/química; Animales; Antiinflamatorios/síntesis química; Antiinflamatorios/química; Inhibidores de la Ciclooxigenasa/síntesis química; Inhibidores de la Ciclooxigenasa/química; Diseño de Fármacos; Concentración 50 Inhibidora; Ratones; Simulación del Acoplamiento Molecular; Quinazolinonas/síntesis química; Análisis Espectral/métodos

Palabras clave

4(3H)-Quinazolinone; Anti-inflammatory activity; COX-1/COX-2 inhibition assay; Docking study; Synthesis

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Inhibidores de la Ciclooxigenasa / Quinazolinonas / Analgésicos / Antiinflamatorios Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article

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