Maraviroc Reduces Arterial Stiffness in PI-Treated HIV-infected Patients.
Sci Rep
; 6: 28853, 2016 06 29.
Article
en En
| MEDLINE
| ID: mdl-27352838
ABSTRACT
The Δ32-CCR5 deletion of the CCR5 receptor is protective toward coronary artery pathology and myocardial infarction. Maraviroc (MVC), a CCR5 antagonist, was recently introduced in the therapy of HIV infection; we evaluated whether this drug could modulate the atherosclerotic burden in aviremic PI-treated HIV-positive individuals who underwent MVC intensification. Thus, the effect of MVC on intima media thickness, arterial stiffness, metabolic parameters, pro-inflammatory cytokines, endothelial dysfunction, and microbial traslocation markers was analyzed in 6 aviremic PI-treated HIV-positive individuals and were compared to those obtained in 9 additional aviremic PI-treated subjects that were enrolled retrospectively from our outpatients cohort. MVC intensification resulted in a significant reduction in intima media thickness, pulse wave velocity and triglycerides compared to baseline. Notably, MVC was also associated with a significant reduction of IL-6, microbial translocation indexes, sICAM and sVCAM; these changes were maintained throughout the 6 months of MVC intensification. No significant modifications were observed in CD4 counts, HIV viral load, and cholesterolemia. Results herein support a role of CCR5 antagonists in reducing the cardiovascular risk in HIV-infection. The hampering of inflammation, microbial translocation and the improvement of endothelial function could justify the protective role of CCR5 antagonists on atherosclerotic burden.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Triazoles
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Infecciones por VIH
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Inhibidores de la Proteasa del VIH
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Ciclohexanos
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Inhibidores de Fusión de VIH
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Aterosclerosis
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Rigidez Vascular
Tipo de estudio:
Etiology_studies
/
Observational_studies
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Risk_factors_studies
Idioma:
En
Revista:
Sci Rep
Año:
2016
Tipo del documento:
Article