Association of genetic variants in the 3'UTR of HLA-G with Recurrent Pregnancy Loss.
Hum Immunol
; 77(10): 886-891, 2016 Oct.
Article
en En
| MEDLINE
| ID: mdl-27370685
ABSTRACT
Human Leukocyte Antigen (HLA)-G is involved in reprogramming immune responses at fetal-maternal interface during pregnancy. We evaluated the genetic diversity of the 3' Un-Translated Region (UTR) of HLA-G, previously associated with HLA-G mRNA post-transcriptional regulation, in women with unexplained Recurrent Pregnancy Loss (RPL), with 2 pregnancy losses (RPL-2, n=28), or 3 or more pregnancy losses (RPL-3, n=24), and in 30 women with a history of successful pregnancy. Results showed in RPL-2, but not in RPL-3, women compared to controls i) higher frequency of the 14bp Ins allele, in single and in double copy; ii) significantly lower frequency of DelG/X genotype, iii) reduced frequency of the UTR-2, and UTR-3 haplotypes; iv) higher frequencies of the UTR-5, UTR-7, and UTR-8 haplotypes. This pilot study supports the relevance of performing 3'UTR HLA-G genetic screening, not limited to a specific polymorphism, but considering the extended haplotypes, as a possible predictor of pregnancy outcome.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Aborto Habitual
/
Regiones no Traducidas 3'
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Antígenos HLA-G
Tipo de estudio:
Diagnostic_studies
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Prognostic_studies
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Risk_factors_studies
País/Región como asunto:
Europa
Idioma:
En
Revista:
Hum Immunol
Año:
2016
Tipo del documento:
Article