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Reduced evolutionary rate in reemerged Ebola virus transmission chains.
Blackley, David J; Wiley, Michael R; Ladner, Jason T; Fallah, Mosoka; Lo, Terrence; Gilbert, Merle L; Gregory, Christopher; D'ambrozio, Jonathan; Coulter, Stewart; Mate, Suzanne; Balogun, Zephaniah; Kugelman, Jeffrey; Nwachukwu, William; Prieto, Karla; Yeiah, Adolphus; Amegashie, Fred; Kearney, Brian; Wisniewski, Meagan; Saindon, John; Schroth, Gary; Fakoli, Lawrence; Diclaro, Joseph W; Kuhn, Jens H; Hensley, Lisa E; Jahrling, Peter B; Ströher, Ute; Nichol, Stuart T; Massaquoi, Moses; Kateh, Francis; Clement, Peter; Gasasira, Alex; Bolay, Fatorma; Monroe, Stephan S; Rambaut, Andrew; Sanchez-Lockhart, Mariano; Scott Laney, A; Nyenswah, Tolbert; Christie, Athalia; Palacios, Gustavo.
Afiliación
  • Blackley DJ; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
  • Wiley MR; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
  • Ladner JT; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
  • Fallah M; Ministry of Health, Monrovia, Liberia.
  • Lo T; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
  • Gilbert ML; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
  • Gregory C; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
  • D'ambrozio J; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
  • Coulter S; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
  • Mate S; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
  • Balogun Z; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
  • Kugelman J; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
  • Nwachukwu W; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
  • Prieto K; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
  • Yeiah A; Ministry of Health, Monrovia, Liberia.
  • Amegashie F; Ministry of Health, Monrovia, Liberia.
  • Kearney B; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
  • Wisniewski M; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
  • Saindon J; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
  • Schroth G; Illumina Inc., San Diego, CA 92122, USA.
  • Fakoli L; Liberian Institute for Biomedical Research, Charlesville, Liberia.
  • Diclaro JW; Naval Medical Research Unit No. 3, U.S. Navy, Cairo, Egypt.
  • Kuhn JH; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA.
  • Hensley LE; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA.
  • Jahrling PB; Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA.
  • Ströher U; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
  • Nichol ST; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
  • Massaquoi M; Ministry of Health, Monrovia, Liberia.
  • Kateh F; Ministry of Health, Monrovia, Liberia.
  • Clement P; World Health Organization, CH-1211 Geneva 27, Switzerland.
  • Gasasira A; World Health Organization, CH-1211 Geneva 27, Switzerland.
  • Bolay F; Liberian Institute for Biomedical Research, Charlesville, Liberia.
  • Monroe SS; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
  • Rambaut A; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK.; Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA.; Centre for Immunology, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3FL, UK.
  • Sanchez-Lockhart M; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
  • Scott Laney A; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
  • Nyenswah T; Ministry of Health, Monrovia, Liberia.
  • Christie A; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
  • Palacios G; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.
Sci Adv ; 2(4): e1600378, 2016 Apr.
Article en En | MEDLINE | ID: mdl-27386513
ABSTRACT
On 29 June 2015, Liberia's respite from Ebola virus disease (EVD) was interrupted for the second time by a renewed outbreak ("flare-up") of seven confirmed cases. We demonstrate that, similar to the March 2015 flare-up associated with sexual transmission, this new flare-up was a reemergence of a Liberian transmission chain originating from a persistently infected source rather than a reintroduction from a reservoir or a neighboring country with active transmission. Although distinct, Ebola virus (EBOV) genomes from both flare-ups exhibit significantly low genetic divergence, indicating a reduced rate of EBOV evolution during persistent infection. Using this rate of change as a signature, we identified two additional EVD clusters that possibly arose from persistently infected sources. These findings highlight the risk of EVD flare-ups even after an outbreak is declared over.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fiebre Hemorrágica Ebola / Ebolavirus Tipo de estudio: Prognostic_studies País/Región como asunto: Africa Idioma: En Revista: Sci Adv Año: 2016 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fiebre Hemorrágica Ebola / Ebolavirus Tipo de estudio: Prognostic_studies País/Región como asunto: Africa Idioma: En Revista: Sci Adv Año: 2016 Tipo del documento: Article