Cytomegalovirus and Epstein-Barr virus reactivation in the intensive care unit.
Med Klin Intensivmed Notfmed
; 112(3): 239-245, 2017 Apr.
Article
en En
| MEDLINE
| ID: mdl-27435067
ABSTRACT
AIM:
The purpose of this work was to evaluate the reactivation of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in immunocompetent patients in the intensive care unit (ICU) and to identify risk factors associated with reactivation. MATERIALS ANDMETHODS:
In this observational prospective study, 60 adult immunocompetent patients who stayed at least 7 days in an ICU were evaluated. During hospitalization, the viral load was monitored at admission and on day 7 with polymerase chain reaction to detect viral reactivation and weekly thereafter on days 14, 21, and 28 if hospitalization continued.RESULTS:
The mean age of patients was 63.3 years (±23.4 years) and 34 (56.7 %) of them were male. Mean APACHE II scores for patients was 25 at admission. Of these patients, 28 were hospitalized in the internal ICU and 32 were hospitalized in the anesthesiology ICU. CMV/EBV reactivation was found in 17 individuals (12 for EBV, 3 for CMV, and 2 for both). The median high-sensitive C-reactive protein value in patients with CMV reactivation was significantly higher than in those patients without CMV reactivation (p = 0.037). EBV reactivation was statistically higher in patients with mechanical ventilation compared to patients without mechanical ventilation (p = 0.023). EBV reactivation in patients with fever was found to be statistically higher than in the patients without fever (p = 0.035).CONCLUSION:
There is a need for extended studies with a larger number of patients from specific groups to better understand the reactivation frequency and identify risk factors. EBV and CMV reactivation should be taken into consideration in critically ill patients with fever, without specific symptoms and unresponsive to the treatment.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Activación Viral
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Infecciones por Citomegalovirus
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Herpesvirus Humano 4
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Infecciones por Virus de Epstein-Barr
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Citomegalovirus
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Unidades de Cuidados Intensivos
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Idioma:
En
Revista:
Med Klin Intensivmed Notfmed
Año:
2017
Tipo del documento:
Article