Constituents from the Roots of Actinidia chinensis and Their Cytochrome P450 Enzyme Inhibitory Activities.
Chem Biodivers
; 13(11): 1454-1459, 2016 Nov.
Article
en En
| MEDLINE
| ID: mdl-27459094
ABSTRACT
A newly discovered triterpenoid, (2α,3ß)-2,3,23-trihydroxyurs-13(18)-en-28-oic acid (1), along with twelve known compounds (2 - 13), were isolated from the roots of Actinidia chinensis Planch (Actinidiaceae). Their chemical structures were determined by 1D- and 2D-NMR spectra and mass spectrometry (MS). The crude extracts and six main constituents (8 - 13) were tested for cytochrome P450 (CYPs) enzyme inhibitory activity. The results showed that, except for compound 8, compounds 9 - 13 had different inhibitory effects on the cytochrome P450 (CYPs) enzyme, and compound 9 significantly inhibited the catalytic activities of CYP3A4 to < 10% of its control activities.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Triterpenos
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Raíces de Plantas
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Sistema Enzimático del Citocromo P-450
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Actinidia
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Inhibidores Enzimáticos del Citocromo P-450
Idioma:
En
Revista:
Chem Biodivers
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2016
Tipo del documento:
Article