Inoculation of Goats, Sheep, and Horses with MERS-CoV Does Not Result in Productive Viral Shedding.
Viruses
; 8(8)2016 08 19.
Article
en En
| MEDLINE
| ID: mdl-27548203
ABSTRACT
The Middle East respiratory syndrome coronavirus (MERS-CoV) was first recognized in 2012 and can cause severe disease in infected humans. Dromedary camels are the reservoir for the virus, although, other than nasal discharge, these animals do not display any overt clinical disease. Data from in vitro experiments suggest that other livestock such as sheep, goats, and horses might also contribute to viral transmission, although field data has not identified any seropositive animals. In order to understand if these animals could be infected, we challenged young goats and horses and adult sheep with MERS-CoV by intranasal inoculation. Minimal or no virus shedding was detected in all of the animals. During the four weeks following inoculation, neutralizing antibodies were detected in the young goats, but not in sheep or horses.
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Base de datos:
MEDLINE
Asunto principal:
Esparcimiento de Virus
/
Infecciones por Coronavirus
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Especificidad del Huésped
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Coronavirus del Síndrome Respiratorio de Oriente Medio
Idioma:
En
Revista:
Viruses
Año:
2016
Tipo del documento:
Article