Synthesis and Pharmacological Evaluation of [11C]Granisetron and [18F]Fluoropalonosetron as PET Probes for 5-HT3 Receptor Imaging.

Mu, Linjing; Müller Herde, Adrienne; Rüefli, Pascal M; Sladojevich, Filippo; Milicevic Sephton, Selena; Krämer, Stefanie D; Thompson, Andrew J; Schibli, Roger; Ametamey, Simon M; Lochner, Martin

Synthesis and Pharmacological Evaluation of [¹¹C]Granisetron and [¹⁸F]Fluoropalonosetron as PET Probes for 5-HT₃ Receptor Imaging.

Mu, Linjing; Müller Herde, Adrienne; Rüefli, Pascal M; Sladojevich, Filippo; Milicevic Sephton, Selena; Krämer, Stefanie D; Thompson, Andrew J; Schibli, Roger; Ametamey, Simon M; Lochner, Martin.

Afiliación

Mu L; Department of Nuclear Medicine, University Hospital Zürich , Rämistrasse 100, 8091 Zürich, Switzerland.
Müller Herde A; Center for Radiopharmaceutical Sciences of ETH, PSI and USZ, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.
Rüefli PM; Department of Chemistry and Biochemistry, University of Bern , Freiestrasse 3, 3012 Bern, Switzerland.
Sladojevich F; Center for Radiopharmaceutical Sciences of ETH, PSI and USZ, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.
Milicevic Sephton S; Center for Radiopharmaceutical Sciences of ETH, PSI and USZ, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.
Krämer SD; Center for Radiopharmaceutical Sciences of ETH, PSI and USZ, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.
Thompson AJ; Department of Pharmacology, University of Cambridge , Tennis Court Road, Cambridge CB2 1PD, United Kingdom.
Schibli R; Center for Radiopharmaceutical Sciences of ETH, PSI and USZ, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.
Ametamey SM; Center for Radiopharmaceutical Sciences of ETH, PSI and USZ, Vladimir-Prelog-Weg 4, 8093 Zürich, Switzerland.
Lochner M; Department of Chemistry and Biochemistry, University of Bern , Freiestrasse 3, 3012 Bern, Switzerland.

ACS Chem Neurosci ; 7(11): 1552-1564, 2016 11 16.

Article en En | MEDLINE | ID: mdl-27571447

Asunto(s)

Granisetrón/síntesis química; Isoquinolinas/síntesis química; Tomografía de Emisión de Positrones; Quinuclidinas/síntesis química; Radiofármacos/síntesis química; Antagonistas del Receptor de Serotonina 5-HT3/síntesis química; Animales; Autorradiografía; Mapeo Encefálico; Radioisótopos de Carbono; Corteza Cerebral/diagnóstico por imagen; Corteza Cerebral/metabolismo; Evaluación Preclínica de Medicamentos; Estabilidad de Medicamentos; Granisetrón/sangre; Granisetrón/química; Granisetrón/farmacología; Células HEK293; Hipocampo/diagnóstico por imagen; Hipocampo/metabolismo; Humanos; Isoquinolinas/sangre; Isoquinolinas/química; Isoquinolinas/farmacología; Masculino; Ratones Endogámicos C57BL; Estructura Molecular; Palonosetrón; Quinuclidinas/sangre; Quinuclidinas/química; Quinuclidinas/farmacología; Radiofármacos/sangre; Radiofármacos/farmacología; Ratas Wistar; Receptores de Serotonina 5-HT3/metabolismo; Antagonistas del Receptor de Serotonina 5-HT3/sangre; Antagonistas del Receptor de Serotonina 5-HT3/farmacología

Palabras clave

5-HT3 receptor; antagonist; granisetron; imaging; palonosetron; positron emission tomography

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Base de datos: MEDLINE Asunto principal: Quinuclidinas / Granisetrón / Radiofármacos / Tomografía de Emisión de Positrones / Antagonistas del Receptor de Serotonina 5-HT3 / Isoquinolinas Idioma: En Revista: ACS Chem Neurosci Año: 2016 Tipo del documento: Article

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