Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapse-associated genes.

Lindqvist, C Mårten; Lundmark, Anders; Nordlund, Jessica; Freyhult, Eva; Ekman, Diana; Carlsson Almlöf, Jonas; Raine, Amanda; Övernäs, Elin; Abrahamsson, Jonas; Frost, Britt-Marie; Grandér, Dan; Heyman, Mats; Palle, Josefine; Forestier, Erik; Lönnerholm, Gudmar; Berglund, Eva C; Syvänen, Ann-Christine

Lindqvist, C Mårten; Lundmark, Anders; Nordlund, Jessica; Freyhult, Eva; Ekman, Diana; Carlsson Almlöf, Jonas; Raine, Amanda; Övernäs, Elin; Abrahamsson, Jonas; Frost, Britt-Marie; Grandér, Dan; Heyman, Mats; Palle, Josefine; Forestier, Erik; Lönnerholm, Gudmar; Berglund, Eva C; Syvänen, Ann-Christine.

Afiliación

Lindqvist CM; Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Lundmark A; Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Nordlund J; Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Freyhult E; Cancer Pharmacology and Computational Medicine, Department of Medical Sciences, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Ekman D; Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Carlsson Almlöf J; Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Raine A; Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Övernäs E; Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Abrahamsson J; Department of Pediatrics, Queen Silvia Children's Hospital, Gothenburg, Sweden.
Frost BM; Nordic Society of Pediatric Hematology and Oncology.
Grandér D; Department of Women's and Children's Health, University Children's Hospital, Uppsala, Sweden.
Heyman M; Nordic Society of Pediatric Hematology and Oncology.
Palle J; Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.
Forestier E; Childhood Cancer Research Unit, Department of Women and Child Health, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.
Lönnerholm G; Nordic Society of Pediatric Hematology and Oncology.
Berglund EC; Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Syvänen AC; Department of Women's and Children's Health, University Children's Hospital, Uppsala, Sweden.

Oncotarget ; 7(39): 64071-64088, 2016 Sep 27.

Article en En | MEDLINE | ID: mdl-27590521

Asunto(s)

Secuenciación de Nucleótidos de Alto Rendimiento; Mutación; Recurrencia Local de Neoplasia/genética; Leucemia-Linfoma Linfoblástico de Células Precursoras/genética; Proteínas Adaptadoras Transductoras de Señales; Niño; Preescolar; Estudios de Cohortes; Análisis Mutacional de ADN; Proteínas de Unión al ADN; Proteína p300 Asociada a E1A/genética; Epigénesis Genética; Humanos; Inmunofenotipificación; Lactante; Péptidos y Proteínas de Señalización Intracelular; Proteínas Nucleares/genética; Proteínas de Fusión Oncogénica/genética; Leucemia-Linfoma Linfoblástico de Células Precursoras B/genética; Leucemia-Linfoma Linfoblástico de Células T Precursoras/genética; Proteínas/genética; Recurrencia; Inducción de Remisión; Análisis de Secuencia de ADN; Factores de Transcripción/genética; Translocación Genética

Palabras clave

acute lymphoblastic leukemia; clonal evolution; relapse; somatic mutation; targeted next generation sequencing

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras / Secuenciación de Nucleótidos de Alto Rendimiento / Mutación / Recurrencia Local de Neoplasia Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Oncotarget Año: 2016 Tipo del documento: Article

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