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Protein-engineering of an amine transaminase for the stereoselective synthesis of a pharmaceutically relevant bicyclic amine.
Weiß, Martin S; Pavlidis, Ioannis V; Spurr, Paul; Hanlon, Steven P; Wirz, Beat; Iding, Hans; Bornscheuer, Uwe T.
Afiliación
  • Weiß MS; Dept of Biotechnology and Enzyme Catalysis, Institute of Biochemistry, University of Greifswald, Felix-Hausdorff-Str. 4, D-17489 Greifswald, Germany. uwe.bornscheuer@uni-greifswald.de.
  • Pavlidis IV; Dept of Biotechnology and Enzyme Catalysis, Institute of Biochemistry, University of Greifswald, Felix-Hausdorff-Str. 4, D-17489 Greifswald, Germany. uwe.bornscheuer@uni-greifswald.de and Group of Biotechnology, Dept of Biochemistry, University of Kassel, Heinrich-Plett-Str. 40, D-34132 Kassel, Germ
  • Spurr P; Process Research and Development, Biocatalysis, F. Hoffmann-La Roche Ltd., Grenzacher Str.124, 4070 Basel, Switzerland. hans.iding@roche.com.
  • Hanlon SP; Process Research and Development, Biocatalysis, F. Hoffmann-La Roche Ltd., Grenzacher Str.124, 4070 Basel, Switzerland. hans.iding@roche.com.
  • Wirz B; Process Research and Development, Biocatalysis, F. Hoffmann-La Roche Ltd., Grenzacher Str.124, 4070 Basel, Switzerland. hans.iding@roche.com.
  • Iding H; Process Research and Development, Biocatalysis, F. Hoffmann-La Roche Ltd., Grenzacher Str.124, 4070 Basel, Switzerland. hans.iding@roche.com.
  • Bornscheuer UT; Dept of Biotechnology and Enzyme Catalysis, Institute of Biochemistry, University of Greifswald, Felix-Hausdorff-Str. 4, D-17489 Greifswald, Germany. uwe.bornscheuer@uni-greifswald.de.
Org Biomol Chem ; 14(43): 10249-10254, 2016 Nov 02.
Article en En | MEDLINE | ID: mdl-27739550
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Base de datos: MEDLINE Asunto principal: Ingeniería de Proteínas / Aminas / Transaminasas Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article
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Base de datos: MEDLINE Asunto principal: Ingeniería de Proteínas / Aminas / Transaminasas Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article